LYC-55716

Product Name: LYC-55716
CAS No.: 2055536-64-4
Chemical Name: LYC-55716
Synonyms: LYC-55716;Cintirorgon);LYC-55716 (LYC55716;Cintirorgon (LYC-55716);Cintirorgon（ LYC-557160;Cintirorgon, 10 mM in DMSO;Cintirorgon (LYC-55716) ，S8860;LYC-55716 (CINTIRORGON) (LYC55716);inhibit,LYC 55716,ROR,RAR-related orphan receptor,LYC55716,Inhibitor,Cintirorgon;9-hydroxy-3-isobutyl-10-methoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one
CBNumber: CB13364616
Molecular Formula: C27H23F6NO6S
Formula Weight: 603.53
MOL File: 2055536-64-4.mol

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LYC-55716 Property

Boiling point:: 669.1±65.0 °C(Predicted)
Density: 1.417±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 100 mg/ml
form: A crystalline solid
pka: 4.68±0.10(Predicted)
color: White to off-white
InChIKey: GULSIMHVQYBADX-XKGZFIRZNA-N
SMILES: S(C1C=CC=C(C(F)(F)F)C=1)(N1C[C@H](CC(C)(C)C(=O)O)OC2=CC=C(C3C=C(F)C=C(OC(F)F)C=3)C=C12)(=O)=O |&1:13,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28425
Product name: Cintirorgon
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 28425
Product name: Cintirorgon
Packaging: 25mg
Price: $1026
Updated: 2024/03/01

Cayman Chemical

Product number: 28425
Product name: Cintirorgon
Packaging: 5mg
Price: $262
Updated: 2024/03/01

Cayman Chemical

Product number: 28425
Product name: Cintirorgon
Packaging: 10mg
Price: $467
Updated: 2024/03/01

ChemScene

Product number: CS-7496
Product name: Cintirorgon
Purity: 99.95%
Packaging: 50mg
Price: $790
Updated: 2021/12/16

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LYC-55716 Chemical Properties,Usage,Production

Uses

Cintirorgon (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival[1][2].

in vivo

Upon oral administration of RORγ agonist Cintirorgon (LYC-55716), this agent selectively binds to the nuclear receptor transcription factor RORγ, forming a receptor complex that translocates to the nucleus, and binds to ROR response elements (ROREs), enhancing the function, proliferation and survival of type 17 T cells, including Th17 (helper T cells) and Tc17 (cytotoxic T cells). RORγ, the nuclear receptor transcription factor that is involved in Th17/Tc17 differentiation, plays a key role in immune activation. Cintirorgon (LYC-55716) is also orally bioavailable, while the new generation of immuno-oncology drugs-ncluding PD-1/PD-L1 inhibitors are delivered by injection^[1].

References

[1] Lycera Announces Initiation of Phase 1/2a Study ARGON of Immuno-Oncology Candidate LYC-55716 in Patients with Advanced Solid Tumors. Jan 04, 2017.

LYC-55716 Preparation Products And Raw materials

Raw materials

Preparation Products

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LYC-55716 Suppliers

China 54 United States 4 USA 1 Global 59

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
Email: market@dingdangchem.com
Country: China
ProdList: 1854
Advantage: 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai Shanyuan pharmaceutical technology co., LTD

Tel: 021-31761238 13167072949
Fax: 021-31761238
Email: 3146446224@qq.com
Country: China
ProdList: 1379
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
Advantage: 62

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Heze Development Zone chuangli Chemical Co., Ltd.

Tel: 0530-+86-530-529 6766，+86-15666160102 15666160102
Fax: 0530-529 6766
Email: info@chuangli-chem.com
Country: China
ProdList: 852
Advantage: 55

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

2055536-64-4, LYC-55716Related Search:

4-tert-Butylcyclohexanone ADOGEN 464

LYC-55716

(S)-3-(6-(3-(difluoromethoxy)-5-fluorophenyl)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid

Cintirorgon)

LYC-55716 (LYC55716

2H-1,4-Benzoxazine-2-propanoic acid, 6-[3-(difluoromethoxy)-5-fluorophenyl]-3,4-dihydro-α,α-dimethyl-4-[[3-(trifluoromethyl)phenyl]sulfonyl]-, (2S)-

Cintirorgon (LYC-55716)

9-hydroxy-3-isobutyl-10-methoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one

Cintirorgon（ LYC-557160

inhibit,LYC 55716,ROR,RAR-related orphan receptor,LYC55716,Inhibitor,Cintirorgon

LYC-55716 (CINTIRORGON) (LYC55716)

Cintirorgon, 10 mM in DMSO

Cintirorgon (LYC-55716) ，S8860

2055536-64-4

C27H23F6NO6S