ChemicalBook > CAS DataBase List > 1-Acetyl-1H-pyrazol-3(2H)-one
1-Acetyl-1H-pyrazol-3(2H)-one
- Product Name
- 1-Acetyl-1H-pyrazol-3(2H)-one
- CAS No.
- 852471-15-9
- Chemical Name
- 1-Acetyl-1H-pyrazol-3(2H)-one
- Synonyms
- 2-acetyl-1H-pyrazol-5-one;1-Acetyl-1H-pyrazol-3(2H)-one;1-Acetyl1,2-dihydro-3H-pyrazole-3-one;1-Acetyl-1,2-dihydro-3h-pyrazol-3-one;1-(3-hydroxy-1H-pyrazol-1-yl)ethanone;1-acetyl-2,3-dihydro-1H-pyrazol-3-one;3H-Pyrazol-3-one, 1-acetyl-1,2-dihydro-;1-neneneba acetyl 1,2-dihydro-3H-pyrazole-3-one
- CBNumber
- CB13367561
- Molecular Formula
- C5H6N2O2
- Formula Weight
- 126.11
- MOL File
- 852471-15-9.mol
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1-Acetyl-1H-pyrazol-3(2H)-one Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to light yellow Solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Matrix Scientific
- Product number
- 178875
- Product name
- 1-(3-Hydroxy-1H-pyrazol-1-yl)ethan-1-one
- Packaging
- 500mg
- Price
- $616
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 178875
- Product name
- 1-(3-Hydroxy-1H-pyrazol-1-yl)ethan-1-one
- Packaging
- 1g
- Price
- $840
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 178875
- Product name
- 1-(3-Hydroxy-1H-pyrazol-1-yl)ethan-1-one
- Packaging
- 5g
- Price
- $3500
- Updated
- 2021/12/16
Crysdot
- Product number
- CD00001468
- Product name
- 1-Acetyl-1H-pyrazol-3(2H)-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $743
- Updated
- 2021/12/16
Alichem
- Product number
- 852471159
- Product name
- 1-Acetyl-1H-pyrazol-3(2H)-one
- Packaging
- 5g
- Price
- $795
- Updated
- 2021/12/16
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1-Acetyl-1H-pyrazol-3(2H)-one Chemical Properties,Usage,Production
Synthesis
108-24-7
137-45-1
852471-15-9
To a 100 mL round-bottomed flask equipped with a magnetic stirrer and a reflux condenser tube, 1,2-dihydro-3H-pyrazol-3-one (4.97 g, 59.11 mmol) and pyridine (25 mL, 309.1 mmol) were added sequentially. The reaction mixture was heated to 95 °C with continuous stirring. A solution consisting of acetic anhydride (5.6 mL, 59.35 mmol) dissolved in pyridine (10 mL, 123.6 mmol) was slowly added dropwise over 3 minutes. After the dropwise addition was completed, the reaction mixture continued to be stirred at 95 °C for 3 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting solid residue was ground with 40 mL of ether, subsequently filtered and washed with ether and finally dried to afford 1-acetyl-1H-pyrazol-3(2H)-one (6.96 g, 93% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 10.96 (s, 1H), 8.13 (d, J = 3.0 Hz, 1H), 6.01 (d, J = 3.0 Hz, 1H), 2.48 (s, 3H).
References
[1] Patent: WO2018/64632, 2018, A1. Location in patent: Paragraph 00650; 00651
[2] Patent: WO2011/26937, 2011, A1. Location in patent: Page/Page column 26
[3] ChemMedChem, 2015, vol. 10, # 7, p. 1184 - 1199
[4] Patent: US2005/165005, 2005, A1. Location in patent: Page/Page column 44
[5] Patent: WO2013/162072, 2013, A1. Location in patent: Page/Page column 960
1-Acetyl-1H-pyrazol-3(2H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
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