ChemicalBook > CAS DataBase List > 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole

7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole

Product Name: 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole
CAS No.: 1415379-56-4
Chemical Name: 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole
Synonyms: T807 (AV1451);T-807; T807; T 807;T807, 10 mM in DMSO;Cedazuridine Impurity 4;7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole;AV 1451,T807,T-807,T 807,AV1451,Inhibitor,inhibit;7-(6-fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole1415379-56-4
CBNumber: CB13367642
Molecular Formula: C16H10FN3
Formula Weight: 263.27
MOL File: 1415379-56-4.mol

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7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole Property

Boiling point:: 535.1±45.0 °C(Predicted)
Density: 1.371±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 16.6 mg/mL (63.05 mM)
pka: 14.13±0.40(Predicted)
form: Solid
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 9878BB
Product name: 7-(6-Fluoropyridin-3-yl)-5h-pyrido[4,3-b]indole
Packaging: 25mg
Price: $527
Updated: 2021/12/16

AK Scientific

Product number: 9878BB
Product name: 7-(6-Fluoropyridin-3-yl)-5h-pyrido[4,3-b]indole
Packaging: 100mg
Price: $928
Updated: 2021/12/16

Crysdot

Product number: CD00009881
Product name: 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole
Purity: 97%
Packaging: 5mg
Price: $84
Updated: 2021/12/16

Crysdot

Product number: CD00009881
Product name: 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole
Purity: 97%
Packaging: 25mg
Price: $243
Updated: 2021/12/16

Crysdot

Product number: CD00009881
Product name: 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole
Purity: 97%
Packaging: 50mg
Price: $441
Updated: 2021/12/16

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7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole Chemical Properties,Usage,Production

Description

T807 is a tau-binding agent.1 It selectively binds to recombinant tau (Kd = 0.2 and 16.8 nM for high- and low-affinity tau binding sites) over 83 receptors, transporters, enzymes, and ion channels in a panel at 10 µM but does bind to monoamine oxidase A (MAO-A) and MAO-B (Kds = 1.6 and 21 nM, respectively). T807 binds to native tau fibrils from patients with Alzheimer’s disease or progressive supranuclear palsy (PSP; Kds = 0.3 nM for both for high-affinity tau binding sites; Kds = 30 and 70 nM, respectively, for low-affinity tau binding sites) but also binds to brain homogenates from patients without a tau-related disease (Kds = 0.6 and 52.5 nM for high- and low-affinity tau binding sites, respectively) due to its off-target binding to MAO-A and MAO-B. A radiolabeled form of T807, 18F-T807, has been used in the imaging of tau in animal models of tau pathology in vivo and in postmortem human brain tissue from patients with Alzheimer’s disease.2 WARNING This product is not for human or veterinary use.

7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole Preparation Products And Raw materials

Raw materials

Preparation Products

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1415379-56-4, 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indoleRelated Search:

7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole

7-(6-fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole1415379-56-4

T-807; T807; T 807

T807 (AV1451)

AV 1451,T807,T-807,T 807,AV1451,Inhibitor,inhibit

Cedazuridine Impurity 4

T807, 10 mM in DMSO

1415379-56-4