Isoquinoline, 1,2-dihydro-1-(1H-indol-3-yl)-2-[(phenylmethyl)sulfonyl]-
- Product Name
- Isoquinoline, 1,2-dihydro-1-(1H-indol-3-yl)-2-[(phenylmethyl)sulfonyl]-
- CAS No.
- 313526-24-8
- Chemical Name
- Isoquinoline, 1,2-dihydro-1-(1H-indol-3-yl)-2-[(phenylmethyl)sulfonyl]-
- Synonyms
- IBR2;IBR2 (IBR 2);IBR2, 10 mM in DMSO;RAD51,Apoptosis,IBR-2,IBR2,inhibit,Inhibitor,IBR 2;2-(Benzylsulfonyl)-1-(1H-indol-3-yl)-1,2-dihydroisoquinoline;2-(Benzylsulfonyl)-1-(1H-indol-3-yl)-1,2-dihydroisoquinoline , IBR2;Isoquinoline, 1,2-dihydro-1-(1H-indol-3-yl)-2-[(phenylmethyl)sulfonyl]-
- CBNumber
- CB13382133
- Molecular Formula
- C24H20N2O2S
- Formula Weight
- 400.49
- MOL File
- 313526-24-8.mol
Isoquinoline, 1,2-dihydro-1-(1H-indol-3-yl)-2-[(phenylmethyl)sulfonyl]- Property
- Boiling point:
- 651.2±65.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 150 mg/mL (374.54 mM)
- form
- Solid
- pka
- 16.67±0.30(Predicted)
- color
- Off-white to pink
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0034478
- Product name
- IBR2
- Purity
- 98.60%
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-0034478
- Product name
- IBR2
- Purity
- 98.60%
- Packaging
- 10mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- CS-0034478
- Product name
- IBR2
- Purity
- 98.60%
- Packaging
- 50mg
- Price
- $520
- Updated
- 2021/12/16
- Product number
- CS-0034478
- Product name
- IBR2
- Purity
- 98.60%
- Packaging
- 100mg
- Price
- $910
- Updated
- 2021/12/16
Isoquinoline, 1,2-dihydro-1-(1H-indol-3-yl)-2-[(phenylmethyl)sulfonyl]- Chemical Properties,Usage,Production
Uses
IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis[1][2].
References
[1] Jiewen Zhu, et al. A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. EMBO Mol Med. 2013 Mar;5(3):353-65. DOI:10.1002/emmm.201201760
[2] Zhu J, et al. Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors. Eur J Med Chem. 2015;96:196-208. DOI:10.1016/j.ejmech.2015.04.021
Isoquinoline, 1,2-dihydro-1-(1H-indol-3-yl)-2-[(phenylmethyl)sulfonyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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