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Fer and FerT inhibitor

Product Name
Fer and FerT inhibitor
CAS No.
1241537-79-0
Chemical Name
Fer and FerT inhibitor
Synonyms
E260;E260 ;E-260 ;E 260;Fer and FerT inhibitor;E-260,Inhibitor,E 260,E260,inhibit;6-(4-isopropylphenyl)-2-[4-[(4-methylpiperazin-1-yl)methyl]-1-piperidyl]imidazo[2,1-b][1,3,4]thiadiazole;6-(4-Isopropylphenyl)-2-(4-((4-methylpiperazin-1-yl)methyl)piperidin-1-yl)imidazo[2,1-b][1,3,4]thiadiazole;Imidazo[2,1-b]-1,3,4-thiadiazole, 6-[4-(1-methylethyl)phenyl]-2-[4-[(4-methyl-1-piperazinyl)methyl]-1-piperidinyl]-
CBNumber
CB13385987
Molecular Formula
C24H34N6S
Formula Weight
438.63
MOL File
1241537-79-0.mol
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Fer and FerT inhibitor Property

Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 1 mg/mL (2.28 mM)
pka
7.66±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed
Product number
A633521
Product name
6-(4-isopropylphenyl)-2-(4-((4-methylpiperazin-1-yl)methyl)piperidin-1-yl)imidazo[2,1-b][1,3,4]thiadiazole
Purity
98%
Packaging
5mg
Price
$52
Updated
2021/12/16
Ambeed
Product number
A633521
Product name
6-(4-isopropylphenyl)-2-(4-((4-methylpiperazin-1-yl)methyl)piperidin-1-yl)imidazo[2,1-b][1,3,4]thiadiazole
Purity
98%
Packaging
10mg
Price
$88
Updated
2021/12/16
Ambeed
Product number
A633521
Product name
6-(4-isopropylphenyl)-2-(4-((4-methylpiperazin-1-yl)methyl)piperidin-1-yl)imidazo[2,1-b][1,3,4]thiadiazole
Purity
98%
Packaging
25mg
Price
$144
Updated
2021/12/16
Ambeed
Product number
A633521
Product name
6-(4-isopropylphenyl)-2-(4-((4-methylpiperazin-1-yl)methyl)piperidin-1-yl)imidazo[2,1-b][1,3,4]thiadiazole
Purity
98%
Packaging
50mg
Price
$229
Updated
2021/12/16
Ambeed
Product number
A633521
Product name
6-(4-isopropylphenyl)-2-(4-((4-methylpiperazin-1-yl)methyl)piperidin-1-yl)imidazo[2,1-b][1,3,4]thiadiazole
Purity
98%
Packaging
100mg
Price
$298
Updated
2021/12/16
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Fer and FerT inhibitor Chemical Properties,Usage,Production

Biological Activity

E260 (Fer and FerT inhibitor E260), an inhibitor of Fer kinase and FerT, selectively induces metabolic stress in cancer cells by reducing cellular ATP levels by imposing mitochondrial dysfunction and deformation and energy-consuming autophagy.

in vivo

E260 suppresses xenografts progression in vivo. The pharmacokinetic (PK) profile of E260 is determined in mice. E260 exhibits a T 1/2 of 175 min in the blood, and a volume of distribution of 4244 mL/kg suggesting an efficient distribution of the compound in the animal tissues. To evaluate the efficacy of E260 on tumor growth, SW620 cells are subcutaneously introduced into immuno-compromised “Nude” mice. Administration of E260 leads to a significant attenuation of tumor progression throughout the experiment, and to a 10-fold decrease in average tumor volume after 22 days of treatment. To further demonstrate the anti-cancer activity of E260 in vivo, mice bearing SW48 cells derived xenografts are treated with E260 and the tumor progression profiles are determined. Mice treated with E260 demonstrate a 5-6-fold attenuation in tumor progression when compared to the control treated group.

target

< tr>
TargetValue
Fer kinase
()
FerT
()

Fer and FerT inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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Fer and FerT inhibitor Suppliers

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1241537-79-0, Fer and FerT inhibitorRelated Search:


  • Fer and FerT inhibitor
  • E260
  • E260 ;E-260 ;E 260
  • 6-(4-Isopropylphenyl)-2-(4-((4-methylpiperazin-1-yl)methyl)piperidin-1-yl)imidazo[2,1-b][1,3,4]thiadiazole
  • Imidazo[2,1-b]-1,3,4-thiadiazole, 6-[4-(1-methylethyl)phenyl]-2-[4-[(4-methyl-1-piperazinyl)methyl]-1-piperidinyl]-
  • E-260,Inhibitor,E 260,E260,inhibit
  • 6-(4-isopropylphenyl)-2-[4-[(4-methylpiperazin-1-yl)methyl]-1-piperidyl]imidazo[2,1-b][1,3,4]thiadiazole
  • 1241537-79-0
  • C24H34N6S