N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide

Product Name: N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide
CAS No.: 1627138-52-6
Chemical Name: N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide
Synonyms: ML380;ML380, 10 mM in DMSO;1-((1H-Indazol-5-yl)sulfonyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide;N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide;4-Piperidinecarboxamide, N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]-;positive,ML380,Muscarinic acetylcholine receptor,allosteric,inhibit,ACh,modulator,Inhibitor,mAChR,PAM
CBNumber: CB13414100
Molecular Formula: C23H25F3N4O3S
Formula Weight: 494.53
MOL File: 1627138-52-6.mol

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N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Property

Boiling point:: 661.2±65.0 °C(Predicted)
Density: 1.388±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 100 mg/mL (202.21 mM)
form: Solid
pka: 12.84±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0011371
Product name: ML380
Purity: 99.91%
Packaging: 5mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-0011371
Product name: ML380
Purity: 99.91%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0011371
Product name: ML380
Purity: 99.91%
Packaging: 25mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0011371
Product name: ML380
Purity: 99.91%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0011371
Product name: ML380
Purity: 99.91%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

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N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Chemical Properties,Usage,Production

Biological Activity

ML380 is a potent, isotype-selective and blood-brain barrier-permeable positive allosteric modulator (PAM) of M5 mAChR with EC50 values of 190 and 610 nM for human and rat M5, respectively.

in vivo

ML380 (1 mg/kg; iv) displays high clearance (66 mL/min/kg), a moderate volume of distribution (1.6 L/kg), and a short half-life (t _1/2 , 22 min) in rats.

target

IC50: 190 nM (hM5), 610 nM (rM5)

N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Suppliers

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1627138-52-6, N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamideRelated Search:

N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide

ML380

positive,ML380,Muscarinic acetylcholine receptor,allosteric,inhibit,ACh,modulator,Inhibitor,mAChR,PAM

4-Piperidinecarboxamide, N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]-

1-((1H-Indazol-5-yl)sulfonyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide

ML380, 10 mM in DMSO

1627138-52-6