L-ERYTHRO-DIHYDROSPHINGOSINE
- Product Name
- L-ERYTHRO-DIHYDROSPHINGOSINE
- CAS No.
- 6036-76-6
- Chemical Name
- L-ERYTHRO-DIHYDROSPHINGOSINE
- Synonyms
- SPC-103980;L-ERYTHRO-SPHINGANINE;L-ERYTHRO-DIHYDROSPHINGOSINE;L-erythro Sphinganine (d18:0);(2R,3S)-2-Amino-1,3-octadecanediol;1,3-Octadecanediol, 2-amino-, (2R,3S)-
- CBNumber
- CB1341816
- Molecular Formula
- C18H39NO2
- Formula Weight
- 301.51
- MOL File
- 6036-76-6.mol
L-ERYTHRO-DIHYDROSPHINGOSINE Property
- Boiling point:
- 446.2±25.0 °C(Predicted)
- Density
- 0.927±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: 25 mg/mL warm
- pka
- 12.57±0.45(Predicted)
- form
- A solid
- color
- white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 24374
- Product name
- L-erythro Sphinganine (d18:0)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $189
- Updated
- 2024/03/01
L-ERYTHRO-DIHYDROSPHINGOSINE Chemical Properties,Usage,Production
Description
L-erythro Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and D-threo sphinganine . It induces autophagy in HCT116 cells when used at a concentration of 12 μM. L-erythro Sphinganine induces cell cycle arrest of 7R4-LCB1 yeast cells. It is metabolized via sphinganine N-acyltransferase and sphinganine kinase in vivo in rat liver. [Matreya, LLC. Catalog No. 1846]
Uses
L-erythro-Dihydrosphingosine is an ester product.
Definition
ChEBI: Erythro-dihydrosphingosine is an amino alcohol.
References
[1] JESSE COWARD. Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway.[J]. Autophagy, 2009, 5 2: 184-193. DOI: 10.4161/auto.5.2.7361
[2] G M JENKINS Y A H. Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.[J]. The Journal of Biological Chemistry, 2001, 276 11: 8574-8581. DOI: 10.1074/jbc.m007425200
[3] W STOFFEL K B. Stereospecificities in the metabolic reactions of the four isomeric sphinganines (dihydrosphingosines) in rat liver.[J]. Hoppe-Seyler’s Zeitschrift fur physiologische Chemie, 1973, 354 2: 169-181. DOI: 10.1515/bchm2.1973.354.1.169
L-ERYTHRO-DIHYDROSPHINGOSINE Preparation Products And Raw materials
Raw materials
Preparation Products
L-ERYTHRO-DIHYDROSPHINGOSINE Suppliers
- Tel
- 0717-6449896 13886658719
- Fax
- 0717-6558598
- root@zhongyitai.com
- Country
- China
- ProdList
- 1978
- Advantage
- 58
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6777
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 11973
- Advantage
- 58
- Tel
- 15102117276 19921389125
- tech@zzbioco.com
- Country
- China
- ProdList
- 12064
- Advantage
- 58
- Tel
- 800-364-9897
- sales@caymanchem.com
- Country
- China
- ProdList
- 6838
- Advantage
- 58
- Tel
- Enzo Biochem Inc. 13797054060
- Enzoname@qq.com
- Country
- China
- ProdList
- 6174
- Advantage
- 58
- Tel
- 18028747627
- Country
- CHINA
- ProdList
- 191
- Advantage
- 58