CHLOROACETYL FLUORIDE Property

Boiling point:

75°C

Density 

1.38 g/cm3

Safety

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

23-26-36/37/39-45

RIDADR 

3265

Hazard Note 

Corrosive

HS Code 

2915907098

Hazard and Precautionary Statements (GHS)

CHLOROACETYL FLUORIDE Chemical Properties,Usage,Production

Uses

Chloroacetyl Fluoride is used as an acylating agent and a precursor to chloroacetylium ion.

Preparation

Chloroacetyl Fluoride is generally prepared by fluorination of ClCH2COCl. A variety of reagents has been employed for this transformation, including benzoyl fluoride/KH2F, KHF2, KF, KF/tetraalkylammonium chloride, and dialkylaminosulfur trifluoride. Preparation of ClCH2COF may also be accomplished from ClCH2CO2H through the use of 2- chloro-1,1,2-trifluoroethyldiethylamine as the fluoride source. Treatment of ClCH2CF2CF2OCH3 with SO3 leads to the formation of ClCH2COF in 94% yield, which is the highest yield reported for the preparation of the reagent.

storage

Chloroacetyl Fluoride is corrosive, moisture sensitive, and should be stored under anhydrous conditions. This reagent should be handled in a fume hood.