ChemicalBook > CAS DataBase List > 6,9ALPHA-METHYLENE-9BETA-METHYL-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, CALCIUM SALT

6,9ALPHA-METHYLENE-9BETA-METHYL-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, CALCIUM SALT

Product Name
6,9ALPHA-METHYLENE-9BETA-METHYL-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, CALCIUM SALT
CAS No.
81703-55-1
Chemical Name
6,9ALPHA-METHYLENE-9BETA-METHYL-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, CALCIUM SALT
Synonyms
U-61431F;CIPROSTENE CALCIUM;CIPROSTENE CALCIUM SALT;9-beta-methylcarbacyclin;WKRNCYQUQFBOCZ-FCIOBEBZSA-M;pentalenylidene)-,calciumsalt(2:1),(3as-(2z,3a-alpha,5-beta,6-alpha(1e,3r*;5-(hexahydro-5-hydroxy-6-(3-hydroxy-1-octenyl)-3a-methyl-2(1h)-pentanoicaci;6,9ALPHA-METHYLENE-9BETA-METHYL-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, CALCIUM SALT
CBNumber
CB1357538
Molecular Formula
C22H38CaO4
Formula Weight
406.62
MOL File
81703-55-1.mol
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6,9ALPHA-METHYLENE-9BETA-METHYL-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, CALCIUM SALT Property

storage temp. 
Store at -20°C
solubility 
DMF: > 25 mg/ml; DMSO: > 16.8 mg/ml; ethanol: > 34 mg/ml; PBS pH 7.2: > 0.29 μg/ml
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18216
Product name
Ciprostene (calcium salt)
Purity
≥98%
Packaging
1mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
18216
Product name
Ciprostene (calcium salt)
Purity
≥98%
Packaging
5mg
Price
$678
Updated
2024/03/01
Cayman Chemical
Product number
18216
Product name
Ciprostene (calcium salt)
Purity
≥98%
Packaging
10mg
Price
$1204
Updated
2024/03/01
AK Scientific
Product number
1674AH
Product name
Ciprostenecalcium
Packaging
1mg
Price
$267
Updated
2021/12/16
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6,9ALPHA-METHYLENE-9BETA-METHYL-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, CALCIUM SALT Chemical Properties,Usage,Production

Description

Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 μg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 μg/kg/min and 60 ng/ml, respectively.

Uses

Platelet aggregation inhibitor.

References

[1] G. ALLAN. The cardiovascular and platelet actions of 9β-methyl carbacyclin (ciprostene), a chemically stable analogue of prostacyclin, in the dog and monkey[J]. British Journal of Pharmacology, 1985, 85 2: 547-555. DOI: 10.1111/j.1476-5381.1985.tb08892.x
[2] PAUL A. ARISTOFF  Allen W H  Paul D Johnson. Synthesis of 9-substituted carbacyclin analogs[J]. The Journal of Organic Chemistry, 1983, 48 26: 5341-5348. DOI: 10.1021/jo00174a035

6,9ALPHA-METHYLENE-9BETA-METHYL-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, CALCIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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6,9ALPHA-METHYLENE-9BETA-METHYL-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, CALCIUM SALT Suppliers

China 19 United States 2 Global 21
Chengdu Saiousi Pharmaceutical Co., Ltd
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81703-55-1, 6,9ALPHA-METHYLENE-9BETA-METHYL-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, CALCIUM SALTRelated Search:

Ciprostene 6,9ALPHA-METHYLENE-9BETA-METHYL-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, CALCIUM SALT

  • CIPROSTENE CALCIUM
  • CIPROSTENE CALCIUM SALT
  • 6,9ALPHA-METHYLENE-9BETA-METHYL-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, CALCIUM SALT
  • U-61431F
  • 5-(hexahydro-5-hydroxy-6-(3-hydroxy-1-octenyl)-3a-methyl-2(1h)-pentanoicaci
  • 9-beta-methylcarbacyclin
  • pentalenylidene)-,calciumsalt(2:1),(3as-(2z,3a-alpha,5-beta,6-alpha(1e,3r*
  • WKRNCYQUQFBOCZ-FCIOBEBZSA-M
  • 81703-55-1