ChemicalBook > CAS DataBase List > 5-bromo-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)quinoxalin-6-amine

5-bromo-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)quinoxalin-6-amine

Product Name
5-bromo-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)quinoxalin-6-amine
CAS No.
1184971-51-4
Chemical Name
5-bromo-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)quinoxalin-6-amine
Synonyms
5-bromo-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)quinoxalin-6-amine;5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl-4,4,5,5-d4)quinoxalin-6-amine
CBNumber
CB13625799
Molecular Formula
C11H10BrN5
Formula Weight
292.14
MOL File
1184971-51-4.mol
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5-bromo-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)quinoxalin-6-amine Property

storage temp. 
Store at -20°C
solubility 
DMSO: soluble; Water: 1.5 mg/ml
form 
A solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25465
Product name
Brimonidine-d4
Purity
≥99% deuterated forms (d1-d4)
Packaging
500μg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
25465
Product name
Brimonidine-d4
Purity
≥99% deuterated forms (d1-d4)
Packaging
1mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
25465
Product name
Brimonidine-d4
Purity
≥99% deuterated forms (d1-d4)
Packaging
5mg
Price
$775
Updated
2024/03/01
AK Scientific
Product number
5496DF
Product name
5-Bromo-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)quinoxalin-6-amine
Packaging
1mg
Price
$299
Updated
2021/12/16
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5-bromo-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)quinoxalin-6-amine Chemical Properties,Usage,Production

Description

Brimonidine-d4 is intended for use as an internal standard for the quantification of brimonidine by GC- or LC-MS. Brimonidine is an agonist of α2-adrenergic receptors (α2-ARs; Kis = 2.7, 52, and 44 nM for α2A, α2B, and α2C-ARs, respectively, in CHO cells).1 It is selective for α2-ARs over α1-ARs (Ki = 1,800 nM in human brain). Brimonidine lowers intraocular pressure in DBA/2J mice, a model of glaucoma, to control levels when applied topically to the eye as a 0.1% solution.2 It also inhibits glutamate release, prevents upregulation of NMDA receptors containing NR1 and NR2A subunits, and protects rat retinal ganglion cells against glutamate excitotoxicity in a rat model of retinal ischemia when administered at a dose of 1 mg/kg per day.3 Formulations containing brimonidine have been used in the treatment of open-angle glaucoma and ocular hypertension.

References

1. Munk, S.A., Harcourt, D.A., Arasasingham, P.N., et al. Synthesis and evaluation of 2-(arylamino)imidazoles as α2-adrenergic agonists J. Med. Chem. 40(1),18-23(1997).
2. Sawada, K., Hiraoka, M., and Ohguro, H. Effect of antiglaucoma medicine on intraocular pressure in DBA/2J mice Ophthalmic Res. 55(4),205-211(2016).
3. Lee, D., Kim, K.Y., Noh, Y.H., et al. Brimonidine blocks glutamate excitotoxicity-induced oxidative stress and preserves mitochondrial transcription factor A in ischemic retinal injury PLoS One 7(10),e47098(2012).

5-bromo-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)quinoxalin-6-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-bromo-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)quinoxalin-6-amine Suppliers

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1184971-51-4, 5-bromo-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)quinoxalin-6-amineRelated Search:

Brimonidine Brimonidine Tartrate Brimonidine Dimer 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine N-(4,5-Dihydro-1H-iMidazol-2-yl)-6-quinoxalinaMine BriMonidine-2,3-dione Brimonidine Impurity E Brimonidine Related Impurity 3 Hydroxy Brimonidine Brimonidine Tartrate Impurity 4 4,5-Didehydro BriMonidine

  • 5-bromo-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)quinoxalin-6-amine
  • 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl-4,4,5,5-d4)quinoxalin-6-amine
  • 1184971-51-4