ChemicalBook > CAS DataBase List > 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

Product Name
3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE
CAS No.
622387-85-3
Chemical Name
3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE
Synonyms
OXSI 2;Syk Inhibitor;3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-2-OXO-1H-INDOLE-5-SULFONAMIDE;3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE;2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide;1H-Indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-;Inhibitor,Tyrosine,OXSI-2,Potassium,Inflammasome,PAR,Pyroptosis,Src,kinase,Piceatannol,Syk,OXSI2,Spleen tyrosine kinase,inhibit,signaling,GPVI,Inflammation
CBNumber
CB1364747
Molecular Formula
C18H15N3O3S
Formula Weight
353.39
MOL File
622387-85-3.mol
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3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Orange powder solid.
color 
Light yellow to brown
Sensitive 
Light Sensitive
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
574711
Product name
Syk Inhibitor - CAS 622387-85-3 - Calbiochem
Packaging
5mg
Price
$163
Updated
2025/07/31
Cayman Chemical
Product number
14829
Product name
Syk Inhibitor
Purity
≥95% (mixture of isomers)
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
14829
Product name
Syk Inhibitor
Purity
≥95% (mixture of isomers)
Packaging
1mg
Price
$55
Updated
2024/03/01
Cayman Chemical
Product number
14829
Product name
Syk Inhibitor
Purity
≥95% (mixture of isomers)
Packaging
10mg
Price
$184
Updated
2024/03/01
Tocris
Product number
6012
Product name
OXSI2
Purity
≥98%(HPLC)
Packaging
10
Price
$185
Updated
2021/12/16
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3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Chemical Properties,Usage,Production

Description

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 14 nM and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM). At 2 μM, this compound completely abolishes convulxin-induced platelet aggregation and shape change.

Uses

OXSI 2 is a Syk selective inhibitor.

References

[1] PAUL J. COX  et al. et al. Potent Small Molecule Inhibitors of Spleen Tyrosine Kinase (Syk).[J]. ChemInform, 2003, 34 51. DOI: 10.1002/chin.200351119
[2] KAMALA BHAVARAJU . Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets[J]. European journal of pharmacology, 2008, 580 3: Pages 285-290. DOI: 10.1016/j.ejphar.2007.11.009

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Suppliers

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622387-85-3, 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDERelated Search:

(Z)-1-METHYL-5-(MORPHOLINOSULFONYL)-3-((1-(3-(O-TOLYLOXY)PROPYL)-1H-INDOL-3-YL)METHYLENE)INDOLIN-2-ONE (Z)-N-CYCLOPENTYL-2-(7-ETHYL-3-((1-METHYL-5-(MORPHOLINOSULFONYL)-2-OXOINDOLIN-3-YLIDENE)METHYL)-1H-INDOL-1-YL)ACETAMIDE (Z)-1-ETHYL-5-(MORPHOLINOSULFONYL)-3-((1-(2-(P-TOLYLOXY)ETHYL)-1H-INDOL-3-YL)METHYLENE)INDOLIN-2-ONE (Z)-2-(7-ETHYL-3-((1-METHYL-5-(MORPHOLINOSULFONYL)-2-OXOINDOLIN-3-YLIDENE)METHYL)-1H-INDOL-1-YL)ACETAMIDE (Z)-3-((1-(3-(2-CHLOROPHENOXY)PROPYL)-1H-INDOL-3-YL)METHYLENE)-1-METHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-1-METHYL-5-(MORPHOLINOSULFONYL)-3-((1-(2-(P-TOLYLOXY)ETHYL)-1H-INDOL-3-YL)METHYLENE)INDOLIN-2-ONE (Z)-3-((7-ETHYL-1-(2-OXO-2-(PIPERIDIN-1-YL)ETHYL)-1H-INDOL-3-YL)METHYLENE)-1-METHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-3-((1-(2-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-2-OXOETHYL)-1H-INDOL-3-YL)METHYLENE)-1-METHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-3-((1-(2-CHLORO-6-FLUOROBENZYL)-1H-INDOL-3-YL)METHYLENE)-1-METHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-1-METHYL-5-(MORPHOLINOSULFONYL)-3-((1-(3-PHENOXYPROPYL)-1H-INDOL-3-YL)METHYLENE)INDOLIN-2-ONE (Z)-1-METHYL-3-((1-(2-(4-METHYLPIPERIDIN-1-YL)-2-OXOETHYL)-1H-INDOL-3-YL)METHYLENE)-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-3-((5-BROMO-1-(2-PHENOXYETHYL)-1H-INDOL-3-YL)METHYLENE)-1-METHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-3-((7-ETHYL-1-(2-MORPHOLINO-2-OXOETHYL)-1H-INDOL-3-YL)METHYLENE)-1-METHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-3-((7-ETHYL-1-(2-OXO-2-(PYRROLIDIN-1-YL)ETHYL)-1H-INDOL-3-YL)METHYLENE)-1-METHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-1-METHYL-3-((1-(2-MORPHOLINO-2-OXOETHYL)-1H-INDOL-3-YL)METHYLENE)-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-3-((5-BROMO-1-(2-PHENOXYETHYL)-1H-INDOL-3-YL)METHYLENE)-1-ETHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-1-METHYL-5-(MORPHOLINOSULFONYL)-3-((1-(2-OXO-2-(PIPERIDIN-1-YL)ETHYL)-1H-INDOL-3-YL)METHYLENE)INDOLIN-2-ONE (Z)-N-(2-METHOXYETHYL)-2-(3-((1-METHYL-5-(MORPHOLINOSULFONYL)-2-OXOINDOLIN-3-YLIDENE)METHYL)-1H-INDOL-1-YL)ACETAMIDE

  • Syk Inhibitor
  • 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE
  • OXSI 2
  • 2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide
  • 3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-2-OXO-1H-INDOLE-5-SULFONAMIDE
  • 1H-Indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-
  • Inhibitor,Tyrosine,OXSI-2,Potassium,Inflammasome,PAR,Pyroptosis,Src,kinase,Piceatannol,Syk,OXSI2,Spleen tyrosine kinase,inhibit,signaling,GPVI,Inflammation
  • 622387-85-3
  • C18H15N3O3S
  • pharmacetical
  • Spleen Tyrosine Kinase Inhibitor