ChemicalBook > CAS DataBase List > 2,2,6,6-Tetramethyl-3,5-heptanedione

2,2,6,6-Tetramethyl-3,5-heptanedione

Product Name
2,2,6,6-Tetramethyl-3,5-heptanedione
CAS No.
1118-71-4
Chemical Name
2,2,6,6-Tetramethyl-3,5-heptanedione
Synonyms
TMHD;2,2,6,6-TETRAMETHYLHEPTANE-3,5-DIONE;DIPIVALOYLMETHANE;2,2,6,6-Tetramethyl heptanedione;2,2,6,6-Tetramethyl-3,5-heptadione;butan-1-ol,propan-2-ol,titanium;3,5-Heptanedione, 2,2,6,6-tetramethyl-;dpm-h;5-heptanedione;6-Tetramethyl-3
CBNumber
CB1373637
Molecular Formula
C11H20O2
Formula Weight
184.28
MOL File
1118-71-4.mol
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2,2,6,6-Tetramethyl-3,5-heptanedione Property

Melting point:
>400 °C (decomp)
Boiling point:
72-73 °C/6 mmHg (lit.)
Density 
0.883 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.459(lit.)
Flash point:
153 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Difficult to mix.
form 
Liquid
pka
11.60±0.10(Predicted)
Specific Gravity
0.883
color 
Clear colorless to slightly yellow
BRN 
1447269
InChIKey
YRAJNWYBUCUFBD-UHFFFAOYSA-N
LogP
2.818 (est)
CAS DataBase Reference
1118-71-4(CAS DataBase Reference)
EPA Substance Registry System
3,5-Heptanedione, 2,2,6,6-tetramethyl- (1118-71-4)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-40-36/37/38
Safety Statements 
24/25-36-26-22
RIDADR 
UN 1993 / PGIII
WGK Germany 
3
TSCA 
T
HS Code 
29141900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H302Harmful if swallowed

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
155756
Product name
2,2,6,6-Tetramethyl-3,5-heptanedione
Purity
98%
Packaging
5g
Price
$49.8
Updated
2024/03/01
Sigma-Aldrich
Product number
155756
Product name
2,2,6,6-Tetramethyl-3,5-heptanedione
Purity
98%
Packaging
25g
Price
$144
Updated
2024/03/01
TCI Chemical
Product number
D1678
Product name
Dipivaloylmethane
Purity
>97.0%(GC)
Packaging
5g
Price
$61
Updated
2024/03/01
TCI Chemical
Product number
D1678
Product name
Dipivaloylmethane
Purity
>97.0%(GC)
Packaging
25g
Price
$173
Updated
2024/03/01
Alfa Aesar
Product number
A15118
Product name
2,2,6,6-Tetramethyl-3,5-heptanedione, 98%
Packaging
5g
Price
$44.65
Updated
2024/03/01
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2,2,6,6-Tetramethyl-3,5-heptanedione Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID

Uses

suzuki reaction

Uses

2,2,6,6-tetramethyl-3,5-heptanedione was used in the synthesis of α-aryl-β-diketones1 and dicyanamidobenzene-bridge diruthenium complex.

Uses

2,2,6,6-Tetramethyl-3,5-heptanedione is a beta diketone with antibacterial activity.

Definition

2,2,6,6-Tetramethyl-3,5-heptanedioneis a stable, anhydrous reagent. It undergoes O-additions and C-additions. In various reactions, it acts as an air-stable ligand for metal catalysts. Furthermore, it serves as a substrate for heterocycles.

Synthesis Reference(s)

Journal of the American Chemical Society, 100, p. 5428, 1978 DOI: 10.1021/ja00485a030

General Description

Acylation, a replacement to silylation, allows the conversion of compounds that consist of active hydrogens (-OH, -SH and -NH) into esters, thioesters, and amides via the action of a carboxylic acid or derivative. The carbonyl group adjacent to the halogenated carbons is known to improve the electron capture detector (ECD) response. Acylation has several advantages:

  • It enhances the stability of compounds by protecting unstable groups.
  • It may confer volatility on substances like carbohydrates or amino acids, that have several polar groups that they are non-volatile and usually decompose on heating.
  • It facilitates the separations not possible with underivatized compounds.
  • Compounds are detectable at very low levels with an ECD.

2,2,6,6-Tetramethyl-3,5-heptanedione is a reagent used to form fragmentation-directing derivatives for GC/MS analysis.

Synthesis

Methyl pivalate and formamide could be used as starting materials to synthesize 2,2,6,6-Tetramethyl-3,5-heptanedione.
   

2,2,6,6-Tetramethyl-3,5-heptanedione Preparation Products And Raw materials

Raw materials

Sodium hydride Ethanol N,N-Dimethylformamide Pinacolone Tetrahydrofuran Diethyl ether Ethyl acetate Methyl trimethylacetate Hydrochloric acid

Preparation Products

N,N-DIPHENYLQUINACRIDONE
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2,2,6,6-Tetramethyl-3,5-heptanedione Suppliers

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View Lastest Price from 2,2,6,6-Tetramethyl-3,5-heptanedione manufacturers

Speranza Chemical Co., Ltd.
Product
2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE 1118-71-4
Price
US $205.00-195.00/KG
Min. Order
25KG
Purity
98%
Supply Ability
500kg
Release date
2023-11-29
Hebei Weibang Biotechnology Co., Ltd
Product
2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE 1118-71-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Hebei Yanxi Chemical Co., Ltd.
Product
2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE 1118-71-4
Price
US $40.00-13.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-13

1118-71-4, 2,2,6,6-Tetramethyl-3,5-heptanedioneRelated Search:

2,4-HEXANEDIONE 2,2,6,6-Tetramethyl-3,5-heptanedione copper(II) derivative, Cu(TMHD)2,2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE, COPPER(II) DERIVATIVE 2,2,6,6-Tetramethyl-3,5-heptanedione 2,2-DIMETHYL-3,5-HEXANEDIONE 3,5-HEPTANEDIONE Barium bis(2,2,6,6-tetramethyl-3,5-heptanedionate) hydrate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) BIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)LEAD(II) GD(TMHD)3 BIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)LEAD(II) 2,2-DIMETHYL-3-HEXANONE 2,6-DIMETHYL-3,5-HEPTANEDIONE BISMUTH TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATE) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)YTTRIUM(III) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)YTTERBIUM 2,6-HEPTANEDIONE 2,2-DIMETHYL-3-HEPTANONE 4,4-DIMETHYL-3-OXO-PENTANAL

  • (CH3)3CCOCH2COC(CH3)3
  • 2,2,6,6-Tetramethyl heptanedione
  • 2,2,6,6-tetramethyl-5-heptanedione
  • TMHD
  • DIPIVALOYLMETHANE
  • 2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE DIPIVALOYLMETHANE
  • 2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE
  • 2,2,6,6-TETRAMETHYLHEPTANE-3,5-DIONE
  • Dipivaloylmethane~Dpm-H~Tmhd-H
  • 2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE, 95 %
  • 2,2,6,6-Tetramethylheptane-3,5-dione,98%TMHD
  • 3,5-Heptanedione, 2,2,6,6-tetramethyl-
  • dpm-h
  • 2,2,6,6-TETRAMETHYLHEPTANE-3,5-DIONE TMHD
  • 2,2,6,6-Tetramethyl-3,5-heptanedione, 99+%
  • 2,2,6,6-Tetramethyl-3,5-heptanedione, 98+%
  • 2,2,6,6-Tetramethyl-3,5-heptadione
  • 1,3-Di-tert-butyl-1,3-propanedione
  • 2,2,6,6-Tetramethylheptane-3,5-dione, 99% TMHD
  • 2,2,6,6-TetraMethyl-3,5-heptanedione, 98% 5GR
  • 2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONE FOR
  • 2,2,6,6-TetraMethyl-3,5-heptan
  • Dipivaloylmethane, 3,5-Dioxo-2,2,6,6-tetramethylheptane
  • 2,2,6,6-TetraMethylheptane-3,5-dione SynonyMs 1,3-Di-tert-butyl-1,3-propanedione
  • 2,2,6,6-Tetramethylheptane-3,5-dione 98%
  • 5-heptanedione
  • 6-Tetramethyl-3
  • Dipivaloylmethane&gt
  • DIPIVALOYALMETHANE
  • -3,5-heptanedione
  • butan-1-ol,propan-2-ol,titanium
  • 2,2,6,6-Tetramethylheptane-3,5-dione 1118-71-4
  • 1118-71-4
  • 11188-71-4
  • C11H20O2
  • KETONE
  • Ligands (Environmentally-friendly Oxidation)
  • Environmentally-friendly Oxidation
  • C11 to C12
  • Carbonyl Compounds
  • Acylation
  • Building Blocks
  • Organic Building Blocks
  • Ketones
  • Achiral Oxygen
  • organic compound
  • Environmentally-friendly Oxidation
  • Ligands (Environmentally-friendly Oxidation)
  • Synthetic Organic Chemistry
  • CHIRAL CHEMICALS