2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
- Product Name
- 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
- CAS No.
- 729589-58-6
- Chemical Name
- 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
- Synonyms
- 2fLI;2-Fly;f-LIGRLO-NH2;2-f-LIGRLO-NH2;2F-LIGRLO-AMIDE;PAR-2 AGONIST II;2-Furoyl-LIGRLO-NH2;2-Furoyl-LIGRLO-amid;2-FUROYL-LIGRLO-AMIDE;2-(2-FUROYL)-LIGRLOAMIDE
- CBNumber
- CB1382037
- Molecular Formula
- C36H63N11O8
- Formula Weight
- 777.95
- MOL File
- 729589-58-6.mol
2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Property
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in H2O
- pka
- 12.91±0.46(Predicted)
- form
- powder
- color
- white
- Water Solubility
- Soluble to 1 mg/ml in water
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F3681
- Product name
- 2-Furoyl-LIGRLO-amide trifluoroacetate salt
- Purity
- ≥97% (HPLC)
- Packaging
- 1mg
- Price
- $171
- Updated
- 2024/03/01
- Product number
- J66850
- Product name
- 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH<sub>2</sub>
- Packaging
- 1mg
- Price
- $70.5
- Updated
- 2021/12/16
- Product number
- J66850
- Product name
- 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH<sub>2</sub>
- Packaging
- 5mg
- Price
- $258
- Updated
- 2021/12/16
- Product number
- 14594
- Product name
- 2-furoyl-LIGRLO amide
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 3015
- Product name
- 2-Furoyl-LIGRLO-amide
- Packaging
- 1
- Price
- $132
- Updated
- 2021/12/16
2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Chemical Properties,Usage,Production
Uses
2-Furoyl-LIGRLO-amide trifluoroacetate salt may be used as a protease-activated receptor 2 (PAR2) agonist in endothelial progenitor cells (EPCs) and in transient receptor potential cation channel subfamily V member (TRPV4)-transfected HEK293t cells.
General Description
2-Furoyl-LIGRLO-amide trifluoroacetate salt is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.
Biological Activity
potent and selective par2 receptor agonist (pd2 = 7.0). causes a dose-dependent relaxation of murine femoral arteries.
Biochem/physiol Actions
2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist. PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+). Immunoblot analysis revealed increases in phosphorylation of epidermal growth factor (EGF) receptor (EGFR) tyrosine kinase, Src, Pyk2, cRaf, and ERK1/2 in response to PAR-2 activation. 2-Furoyl-LIGRLO-amide is nearly 100-fold more potent than SLIGRL-NH2 (Cat. No. S9317). 2-Furoyl-LIGRLO-amide caused both an endothelium-dependent relaxation and an endothelium-independent contraction. It produced delayed (6 hours later) facilitation of capsaicin-evoked visceral nociception, an effect being much more potent than SLIGRL-NH2. Such effects were mimicked by i.col. trypsin. 2-f-LIGRL-NH2, coadministered repeatedly with caerulein six times in total, abolished the caerulein-evoked abdominal hyperalgesia/allodynia in WT, but not PAR2-KO, mice. Repeated doses of 2-f-LIGRL-NH2 moderately attenuated the severity of caerulein-induced pancreatitis in WT animals. It induced a similar dose-dependent increase in Ca2 levels in the presence and absence of b-arrestins.
storage
Store at -20°C
2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 manufacturers
- Product
- 2-Furoyl-LIGRLO-amide trifluoroacetate salt 729589-58-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18
- Product
- 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 729589-58-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18