2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

ChemicalBook > CAS DataBase List > 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

Product Name: 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
CAS No.: 729589-58-6
Chemical Name: 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
Synonyms: 2fLI;2-Fly;f-LIGRLO-NH2;2-f-LIGRLO-NH2;2F-LIGRLO-AMIDE;PAR-2 AGONIST II;2-Furoyl-LIGRLO-NH2;2-Furoyl-LIGRLO-amid;2-FUROYL-LIGRLO-AMIDE;2-(2-FUROYL)-LIGRLOAMIDE
CBNumber: CB1382037
Molecular Formula: C36H63N11O8
Formula Weight: 777.95
MOL File: 729589-58-6.mol

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2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Property

Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in H2O
pka: 12.91±0.46(Predicted)
form: powder
color: white
Water Solubility: Soluble to 1 mg/ml in water

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F3681
Product name: 2-Furoyl-LIGRLO-amide trifluoroacetate salt
Purity: ≥97% (HPLC)
Packaging: 1mg
Price: $171
Updated: 2024/03/01

Alfa Aesar

Product number: J66850
Product name: 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH<sub>2</sub>
Packaging: 1mg
Price: $70.5
Updated: 2021/12/16

Alfa Aesar

Product number: J66850
Product name: 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH<sub>2</sub>
Packaging: 5mg
Price: $258
Updated: 2021/12/16

Cayman Chemical

Product number: 14594
Product name: 2-furoyl-LIGRLO amide
Purity: ≥95%
Packaging: 1mg
Price: $116
Updated: 2024/03/01

Tocris

Product number: 3015
Product name: 2-Furoyl-LIGRLO-amide
Packaging: 1
Price: $132
Updated: 2021/12/16

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2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Chemical Properties,Usage,Production

Uses

2-Furoyl-LIGRLO-amide trifluoroacetate salt may be used as a protease-activated receptor 2 (PAR2) agonist in endothelial progenitor cells (EPCs) and in transient receptor potential cation channel subfamily V member (TRPV4)-transfected HEK293t cells.

General Description

2-Furoyl-LIGRLO-amide trifluoroacetate salt is a peptide that acts as a proteinase-activated receptor-2 (PAR₂) agonist, and contains a furoyl group addition at its N-terminal.

Biological Activity

potent and selective par2 receptor agonist (pd2 = 7.0). causes a dose-dependent relaxation of murine femoral arteries.

Biochem/physiol Actions

2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist. PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+). Immunoblot analysis revealed increases in phosphorylation of epidermal growth factor (EGF) receptor (EGFR) tyrosine kinase, Src, Pyk2, cRaf, and ERK1/2 in response to PAR-2 activation. 2-Furoyl-LIGRLO-amide is nearly 100-fold more potent than SLIGRL-NH2 (Cat. No. S9317). 2-Furoyl-LIGRLO-amide caused both an endothelium-dependent relaxation and an endothelium-independent contraction. It produced delayed (6 hours later) facilitation of capsaicin-evoked visceral nociception, an effect being much more potent than SLIGRL-NH2. Such effects were mimicked by i.col. trypsin. 2-f-LIGRL-NH2, coadministered repeatedly with caerulein six times in total, abolished the caerulein-evoked abdominal hyperalgesia/allodynia in WT, but not PAR2-KO, mice. Repeated doses of 2-f-LIGRL-NH2 moderately attenuated the severity of caerulein-induced pancreatitis in WT animals. It induced a similar dose-dependent increase in Ca2 levels in the presence and absence of b-arrestins.

storage

Store at -20°C

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 manufacturers

Career Henan Chemical Co

Product: 2-Furoyl-LIGRLO-amide trifluoroacetate salt 729589-58-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

Career Henan Chemical Co

Product: 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 729589-58-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

729589-58-6, 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2Related Search:

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

PAR-2 AGONIST II

PROTEINASE ACTIVATED RECEPTOR-2 AGONIST II

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

2-(2-FUROYL)-LIGRLOAMIDE

2-(2-FUROYL)-PAR-2 (2-6)-ORN AMIDE (MOUSE, RAT)

2F-LIGRLO-AMIDE

2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2

2-FUROYL-LIGRLO-AMIDE

(2-Furoyl)-PAR-2 (2-6)-Orn amide (mouse, rat)

2fLI

2-f-LIGRLO-NH2

2-Fly

2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt

2-Furoyl-LIGRLO-amide trifluoroacetate salt

f-LIGRLO-NH2

2-Furoyl-LIGRLO-NH2 Potent and Selective Protease-Activated Receptor 2 (PAR2) Agonist

L-Ornithinamide, N-(2-furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl-

N-(2-Furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl-L-ornithinamide

2-Furoyl-LIGRLO-amid

2-Furoyl-LIGRLO-NH2

Potent and Selective Protease-Activated Receptor2 (PAR2) Agonist

{Fur-2-oyl}-LIGRL-{Orn}-NH2

2-Furoyl-LIGRLO-amide (2Fly), PAR2 agonist

729589-58-6

C36H63N11O8