ChemicalBook > CAS DataBase List > 2-(2-methylbutylamino)-1-[4-[(3-methylphenoxy)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone:hydrochloride
2-(2-methylbutylamino)-1-[4-[(3-methylphenoxy)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone:hydrochloride
- Product Name
- 2-(2-methylbutylamino)-1-[4-[(3-methylphenoxy)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone:hydrochloride
- CAS No.
- 1782573-67-4
- Chemical Name
- 2-(2-methylbutylamino)-1-[4-[(3-methylphenoxy)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone:hydrochloride
- Synonyms
- RU-SKI 43 HCL;HHAT INHIBITOR;RUSKI 43 hydrochloride,RU SKI 43 hydrochloride;2-(2-methylbutylamino)-1-[4-[(3-methylphenoxy)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone:hydrochloride
- CBNumber
- CB13831060
- Molecular Formula
- C22H31ClN2O2S
- Formula Weight
- 423.01
- MOL File
- 1782573-67-4.mol
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2-(2-methylbutylamino)-1-[4-[(3-methylphenoxy)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone:hydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
- form
- A crystalline solid
- color
- White to off-white
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 16972
- Product name
- RU-SKI 43 (hydrochloride)
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 16972
- Product name
- RU-SKI 43 (hydrochloride)
- Packaging
- 10mg
- Price
- $213
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 16972
- Product name
- RU-SKI 43 (hydrochloride)
- Packaging
- 5mg
- Price
- $142
- Updated
- 2024/03/01
Axon Medchem
- Product number
- Axon2035
- Product name
- RU-SKI43hydrochloride
- Purity
- 99%
- Packaging
- 2x5mg
- Price
- $176
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-3457
- Product name
- RU-SKI43hydrochloride
- Purity
- 98.54%
- Packaging
- 10mg
- Price
- $192
- Updated
- 2021/12/16
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2-(2-methylbutylamino)-1-[4-[(3-methylphenoxy)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone:hydrochloride Chemical Properties,Usage,Production
Description
Hedgehog acyltransferase (Hhat) is an N-palmitoyltransferase that acylates Sonic hedgehog (Shh), which is critical for signaling through Shh. RU-SKI 43 is an inhibitor of Hhat (IC50 = 0.85 μM). It blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a. RU-SKI 43 is cell-permeable and inhibits both autocrine and paracrine Shh-induced activation of Gli-mediated transcription. In pancreatic cancer cells, RU-SKI 43 reduces both Gli1 activation and proliferation.
2-(2-methylbutylamino)-1-[4-[(3-methylphenoxy)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone:hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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2-(2-methylbutylamino)-1-[4-[(3-methylphenoxy)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone:hydrochloride Suppliers
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