1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine
- Product Name
- 1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine
- CAS No.
- 880813-42-3
- Chemical Name
- 1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine
- Synonyms
- CMP5,CMP 5;CMP-5 (PRMT5-IN-5);9H-Carbazole-3-methanamine, 9-ethyl-N-(2-pyridinylmethyl)-;1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine
- CBNumber
- CB13843906
- Molecular Formula
- C21H21N3
- Formula Weight
- 315.41
- MOL File
- 880813-42-3.mol
1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine Property
- Boiling point:
- 505.1±48.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 125 mg/mL (396.31 mM)
- form
- Oil
- pka
- 7.28±0.20(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- CS-0076983
- Product name
- CMP-5
- Purity
- 98.69%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-0076983
- Product name
- CMP-5
- Purity
- 98.69%
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-0076983
- Product name
- CMP-5
- Purity
- 98.69%
- Packaging
- 50mg
- Price
- $450
- Updated
- 2021/12/16
1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine Chemical Properties,Usage,Production
Uses
CMP-5 is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 prevents Epstein-Barr virus (EBV)-driven B-lymphocyte transformation but leaving normal B cells unaffected[1][2].
IC 50
PRMT5
References
[1] Alinari L, et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.Blood. 2015 Apr 16;125(16):2530-43. DOI:10.1182/blood-2014-12-619783
[2] Webb LM, et al. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol.2017Feb 15;198(4):1439-1451. DOI:10.4049/jimmunol.1601702
1-(9-ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine Preparation Products And Raw materials
Raw materials
Preparation Products
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