ChemicalBook > CAS DataBase List > 1-(3-BROMOPHENYL)PYRROLIDINE
1-(3-BROMOPHENYL)PYRROLIDINE
Application- Product Name
- 1-(3-BROMOPHENYL)PYRROLIDINE
- CAS No.
- 219928-13-9
- Chemical Name
- 1-(3-BROMOPHENYL)PYRROLIDINE
- Synonyms
- N-(3-BROMOPHENYL)PYRROLIDINE;1-(3-BROMOPHENYL)PYRROLIDINE;1-(3-Bromophenyl)pyrrolidine97%;Pyrrolidine, 1-(3-broMophenyl)-;1-(3-Bromophenyl)pyrrolidine 97%
- CBNumber
- CB1384763
- Molecular Formula
- C10H12BrN
- Formula Weight
- 226.11
- MOL File
- 219928-13-9.mol
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1-(3-BROMOPHENYL)PYRROLIDINE Property
- Boiling point:
- 76/0.1mm
- Density
- 1.411±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.51±0.40(Predicted)
- Appearance
- Off-white to brown Solid
- CAS DataBase Reference
- 219928-13-9
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Safety
- Hazard Note
- Harmful
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- B678323
- Product name
- 1-(3-Bromophenyl)pyrrolidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB153571
- Product name
- 1-(3-Bromophenyl)pyrrolidine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB153571
- Product name
- 1-(3-Bromophenyl)pyrrolidine
- Packaging
- 1g
- Price
- $112.5
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0015039
- Product name
- 1-(3-BROMOPHENYL)PYRROLIDINE
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $117.6
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 119763
- Product name
- 1-(3-Bromophenyl)pyrrolidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $162
- Updated
- 2021/12/16
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1-(3-BROMOPHENYL)PYRROLIDINE Chemical Properties,Usage,Production
Application
1-(3-bromophenyl)pyrrole is a heterocyclic organic compound that can be used to prepare lithium 3-(pyrrolidin-1-yl)benzenesulfinate.
Synthesis
123-75-1
108-36-1
219928-13-9
1. To a 500 mL three-necked round-bottomed flask was added a toluene solution (300 mL) of 1,3-dibromobenzene (20 g, 84.78 mmol, 1.00 eq.) under nitrogen protection. 2. To the reaction system was added pyrrolidine (6.03 g, 84.80 mmol, 1.00 eq.), Pd(OAc)2 (190 mg, 0.85 mmol, 0.01 eq.), BINAP (760 mg, 2.53 mmol, 0.03 eq.) and Cs2CO3 (69.1 g, 211.96 mmol, 2.50 equivalent). 3. The reaction mixture was stirred in an oil bath at 120 °C overnight and the progress of the reaction was monitored by TLC (Expander: EtOAc/PE = 1:5). 4. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure by rotary evaporator. 5. The residue was purified by column chromatography (eluent: PE) to afford 8.51 g (45% yield) of 1-(3-bromophenyl)pyrrolidine as a pale yellow liquid. 6. The product was analyzed by LC-MS. 6. The product was characterized by LC-MS: [M+H]+ m/z calculated value C10H13BrN 226, measured value 226.
References
[1] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 24, p. 6427 - 6434
[2] Tetrahedron, 2008, vol. 64, # 13, p. 2938 - 2950
[3] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0165
[4] Patent: US2008/318941, 2008, A1. Location in patent: Page/Page column 44
[5] Patent: US2008/200471, 2008, A1. Location in patent: Page/Page column 66
1-(3-BROMOPHENYL)PYRROLIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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219928-13-9, 1-(3-BROMOPHENYL)PYRROLIDINERelated Search:
1-(3-BROMOPHENYL)PYRROLIDINE
2-(2-Bromophenyl)pyrrolidine
(R)-2-(2-BROMOPHENYL)PYRROLIDINE
(S)-2-(2-BROMOPHENYL)PYRROLIDINE
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(R)-2-(4-BROMOPHENYL)PYRROLIDINE
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(R)-2-(3-BROMOPHENYL)PYRROLIDINE
(3S,4R)-4-(3-BROMOPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID
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3-(2-BROMOPHENYL)PYRROLIDINE