ChemicalBook > CAS DataBase List > 3',4',5,7-TETRAHYDROXYISOFLAVONE

3',4',5,7-TETRAHYDROXYISOFLAVONE

Product Name: 3',4',5,7-TETRAHYDROXYISOFLAVONE
CAS No.: 480-23-9
Chemical Name: 3',4',5,7-TETRAHYDROXYISOFLAVONE
Synonyms: Orbol;Orobo;OROBOL;isoluteolin;3'-Hydroxygenistein;5,7,3’,4’-tetrahydroxyisoflavone;3’,4’,5,7-tetrahydroxy-isoflavon;3',4',5,7-TETRAHYDROXYISOFLAVONE;3',4',5,7-Tetrahydroxyisoflavone Orobol;3'-Hydroxygenistein|||3’,4’,5,7-tetrahydroxy-isoflavon
CBNumber: CB1391240
Molecular Formula: C15H10O6
Formula Weight: 286.24
MOL File: 480-23-9.mol

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3',4',5,7-TETRAHYDROXYISOFLAVONE Property

Melting point:: 270 °C
Boiling point:: 616.1±55.0 °C(Predicted)
Density: 1.654±0.06 g/cm3(Predicted)
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder
pka: 6.37±0.20(Predicted)
color: Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FO137892
Product name: Orobol
Packaging: 500ug
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FO137892
Product name: Orobol
Packaging: 1mg
Price: $175
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FO137892
Product name: Orobol
Packaging: 2mg
Price: $280
Updated: 2021/12/16

AK Scientific

Product number: W1721
Product name: Orobol
Packaging: 1mg
Price: $286
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000208
Product name: 3',4',5,7-TETRAHYDROXY ISOFLAVONE
Purity: 95.00%
Packaging: 5MG
Price: $500.58
Updated: 2021/12/16

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3',4',5,7-TETRAHYDROXYISOFLAVONE Chemical Properties,Usage,Production

Uses

Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ)[1][2].

Definition

ChEBI: Orobol is a member of the class of 7-hydroxyisoflavones which consists of isoflavone substituted by hydroxy groups at positions 5, 7, 3' and 4'. It has been isolated from the mycelia of Cordyceps sinensis. It has a role as an anti-inflammatory agent, a radical scavenger, a plant metabolite and a fungal metabolite. It is functionally related to an isoflavone.

in vivo

Orobol attenuates high fat diet-induced weight gain and lipid accumulation without affecting food intake in C57BL/6J mice^[2].

Animal Model:	HFD-induced obesity in C57BL/6J mice^[2]
Dosage:	10?mg/kg
Administration:	Intragastrically; daily for 23 weeks
Result:	Significantly reduced body weight by 17.3% compared to the HFD group.

target

References

[1] Kim MH, et al. Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol. Pharmaceutics. 2020;12(9):845. Published 2020 Sep 3. DOI:10.3390/pharmaceutics12090845

3',4',5,7-TETRAHYDROXYISOFLAVONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3',4',5,7-TETRAHYDROXYISOFLAVONE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Orobol 480-23-9
Price: US $1.00-2.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20000KG
Release date: 2024-08-09

480-23-9, 3',4',5,7-TETRAHYDROXYISOFLAVONERelated Search:

LUTEOLIN-3',7-DI-O-GLUCOSIDE 5-HYDROXYDEQUELIN 5,7,3',4'-TETRAMETHOXYISOFLAVONE 3'-O-METHYLPRATENSEIN OROBOL 7,4'-DIMETHYL ETHER OROBOL 7,3',4'-TRIMETHYL ETHER PRATENSEIN 3',4',5,7-TETRAHYDROXYISOFLAVONE ISOPOMIFERIN 6'-METHOXY-2'-PRENYL-5,7,3',4'-TETRAHYDROXYISOFLAVONE 5,7-DIHYDROXY-3',4'-METHYLENEDIOXYISOFLAVONE 5-METHOXYDURMILLONE POMIFERIN OROBOL 7,3'-DIMETHYL ETHER 7-METHOXY-3',4',5-TRIHYDROXYISOFLAVONE ISOPOMIFERIN-3',4'-DIMETHYL ETHER 5-METHOXYMETHYLACICERONE OROBOL-3'-METHYL ETHER

OROBOL

3’,4’,5,7-tetrahydroxy-isoflavon

5,7,3’,4’-tetrahydroxyisoflavone

5,7-dihydroxy-3-(3,4-dihydroxyphenyl)-4h-1-benzopyran-4-on

5,7-dihydroxy-3-(3,4-dihydroxyphenyl)-4h-1-benzopyran-4-one

isoluteolin

3-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one

3'-Hydroxygenistein

3',4',5,7-TETRAHYDROXYISOFLAVONE

3',4',5,7-Tetrahydroxyisoflavone Orobol

4H-1-Benzopyran-4-one, 3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-

Orbol

Orobo

3'-Hydroxygenistein|||3’,4’,5,7-tetrahydroxy-isoflavon

480-23-9

Iso-Flavones