ChemicalBook > CAS DataBase List > AB-423

AB-423

Product Name: AB-423
CAS No.: 1572510-80-5
Chemical Name: AB-423
Synonyms: AB-423;CS-2686;AB-423 (AB423;AB423;AB-423;AB 423;AB-423, 10 mM in DMSO;AB 423,HBV,AB423,inhibit,Hepatitis B virus,AB-423,Inhibitor;5-[[(2R)-butan-2-yl]sulfamoyl]-N-(3,4-difluorophenyl)-2-fluorobenzamide;N-(3,4-Difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]benzamide;Benzamide, N-(3,4-difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]-
CBNumber: CB13960102
Molecular Formula: C17H17F3N2O3S
Formula Weight: 386.39
MOL File: 1572510-80-5.mol

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AB-423 Property

Density: 1.372±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:88.5(Max Conc. mg/mL);229.04(Max Conc. mM)
Ethanol:77.0(Max Conc. mg/mL);199.28(Max Conc. mM)
form: Solid
pka: 10.84±0.70(Predicted)
color: White to off-white
CAS DataBase Reference: 1572510-80-5

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D447900
Product name: N-(3,4-Difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]benzamide
Packaging: 1mg
Price: $165
Updated: 2021/12/16

TRC

Product number: D447900
Product name: N-(3,4-Difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]benzamide
Packaging: 5mg
Price: $495
Updated: 2021/12/16

ChemScene

Product number: CS-0043473
Product name: AB-423
Purity: 99.60%
Packaging: 5mg
Price: $210
Updated: 2021/12/16

ChemScene

Product number: CS-0043473
Product name: AB-423
Purity: 99.60%
Packaging: 10mg
Price: $330
Updated: 2021/12/16

ChemScene

Product number: CS-0043473
Product name: AB-423
Purity: 99.60%
Packaging: 25mg
Price: $660
Updated: 2021/12/16

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AB-423 Chemical Properties,Usage,Production

Uses

N-(3,4-Difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]benzamide, is an inhibitor of HBV capsid assembly. AB-423 shows inhibitory effect on rcDNA production in AML12-HBV10 and HepDE19 cells with EC50s of ～0.260 μM

in vivo

AB-423 (30 and 100 mg/kg, p.o. bid) blocks HBV replication in a mouse model of HBV. AB-423 (100 mg/kg, p.o. bid) with entecavir (ETV, 100 ng/mg, qd, p.o.) or 0.1 mg/kg dose of ARB-1467 potently inhibits serum HBV DNA in an HDI model of HBV in immunodeficient NOD-SCID mice^[1].

AB-423 Preparation Products And Raw materials

Raw materials

Preparation Products

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1572510-80-5, AB-423Related Search:

AB-423

CS-2686

AB423;AB-423;AB 423

Benzamide, N-(3,4-difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]-

N-(3,4-Difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]benzamide

AB 423,HBV,AB423,inhibit,Hepatitis B virus,AB-423,Inhibitor

AB-423, 10 mM in DMSO

AB-423 (AB423

5-[[(2R)-butan-2-yl]sulfamoyl]-N-(3,4-difluorophenyl)-2-fluorobenzamide

1572510-80-5