Dutogliptin tartrate
- Product Name
- Dutogliptin tartrate
- CAS No.
- 890402-81-0
- Chemical Name
- Dutogliptin tartrate
- Synonyms
- PHX-1149;Fotagliptin benzoate;Dutogliptin tartrate
- CBNumber
- CB13975342
- Molecular Formula
- C14H26BN3O9
- Formula Weight
- 391.18
- MOL File
- 890402-81-0.mol
N-Bromosuccinimide Price
- Product number
- D-2654
- Product name
- DutogliptinTartrate
- Packaging
- 10mg
- Price
- $1990
- Updated
- 2021/12/16
Dutogliptin tartrate Chemical Properties,Usage,Production
Uses
Dutogliptin tartrate (PHX-1149) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.
in vivo
Dutogliptin exhibits low plasma protein binding (11%) and is rapidly absorbed with a Tmax of 3-4 h and a half-life of 10-13 h. Dutogliptin is metabolically stable and does not inhibit or induce the activity of major CYP450s[2].
References
[1] Marier JF, et al. Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor. Clin Pharmacol Drug Dev. 2014 Jul;3(4):297-304. DOI:10.1002/cpdd.87
[2] Pattzi HM, et al. Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab. 2010 Apr;12(4):348-55. DOI:10.1111/j.1463-1326.2010.01195.x
Dutogliptin tartrate Preparation Products And Raw materials
Raw materials
Preparation Products
Dutogliptin tartrate Suppliers
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