1,3-DICHLORO-5-[(1E)-2(4-TRIFLUOROMETHYLPHENYL)ETHENYL]-BENZENE

Product Name: 1,3-DICHLORO-5-[(1E)-2(4-TRIFLUOROMETHYLPHENYL)ETHENYL]-BENZENE
CAS No.: 688348-33-6
Chemical Name: 1,3-DICHLORO-5-[(1E)-2(4-TRIFLUOROMETHYLPHENYL)ETHENYL]-BENZENE
Synonyms: CAY10465;CAY10465 Exclusive;CAY 10465, 10 mM in DMSO;CAY10465;CAY-10465;CAY 10465;1,3-Dichloro-5-(4-(trifluoromethyl)styryl)benzene;1,3-DICHLORO-5-[(1E)-2(4-TRIFLUOROMETHYLPHENYL)ETHENYL]-BENZENE;1,3-dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}benzene;CAY-10465,AhR,CAY 10465,inhibit,Inhibitor,Aryl Hydrocarbon Receptor;Benzene, 1,3-dichloro-5-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-
CBNumber: CB1397651
Molecular Formula: C15H9Cl2F3
Formula Weight: 317.13
MOL File: Mol file

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1,3-DICHLORO-5-[(1E)-2(4-TRIFLUOROMETHYLPHENYL)ETHENYL]-BENZENE Property

Boiling point:: 361.2±42.0 °C(Predicted)
Density: 1.378±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:1): .5 mg/ml; Ethanol: 20 mg/ml
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10006546
Product name: CAY10465
Purity: ≥98%
Packaging: 1mg
Price: $22
Updated: 2024/03/01

Cayman Chemical

Product number: 10006546
Product name: CAY10465
Purity: ≥98%
Packaging: 5mg
Price: $95
Updated: 2024/03/01

Cayman Chemical

Product number: 10006546
Product name: CAY10465
Purity: ≥98%
Packaging: 10mg
Price: $167
Updated: 2024/03/01

Cayman Chemical

Product number: 10006546
Product name: CAY10465
Purity: ≥98%
Packaging: 50mg
Price: $723
Updated: 2024/03/01

TRC

Product number: T790970
Product name: (E)-1-[4-(Trifluoromethyl)phenyl]-2-(3,5-dichlorophenyl)ethene
Packaging: 1mg
Price: $85
Updated: 2021/12/16

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1,3-DICHLORO-5-[(1E)-2(4-TRIFLUOROMETHYLPHENYL)ETHENYL]-BENZENE Chemical Properties,Usage,Production

Description

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. CAY10465 is an analog of resveratrol acting as a potent and selective AhR agonist, with a K_i of 0.2 nM. CAY10465 is inactive as a ligand for the estrogen receptor even at 100 μM.

Uses

(E)-1-[4-(Trifluoromethyl)phenyl]-2-(3,5-dichlorophenyl)ethene is a stilbene derivative of resveratrol and a selective aryl hydrocarbon receptor agonist.

References

[1] MICHAEL S DENISON Scott R N. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.[J]. Annual review of pharmacology and toxicology, 2003, 43: 309-334. DOI: 10.1146/annurev.pharmtox.43.100901.135828
[2] PHILIPPE DE MEDINA. Synthesis and Biological Properties of New Stilbene Derivatives of Resveratrol as New Selective Aryl Hydrocarbon Modulators[J]. Journal of Medicinal Chemistry, 2004, 48 1: 287-291. DOI: 10.1021/jm0498194

1,3-DICHLORO-5-[(1E)-2(4-TRIFLUOROMETHYLPHENYL)ETHENYL]-BENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-DICHLORO-5-[(1E)-2(4-TRIFLUOROMETHYLPHENYL)ETHENYL]-BENZENE Suppliers

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688348-33-6, 1,3-DICHLORO-5-[(1E)-2(4-TRIFLUOROMETHYLPHENYL)ETHENYL]-BENZENERelated Search:

CAY10465

1,3-DICHLORO-5-[(1E)-2(4-TRIFLUOROMETHYLPHENYL)ETHENYL]-BENZENE

1,3-dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}benzene

CAY10465 Exclusive

CAY10465;CAY-10465;CAY 10465

CAY-10465,AhR,CAY 10465,inhibit,Inhibitor,Aryl Hydrocarbon Receptor

Benzene, 1,3-dichloro-5-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-

1,3-Dichloro-5-(4-(trifluoromethyl)styryl)benzene

CAY 10465, 10 mM in DMSO

688348-33-6