ChemicalBook > CAS DataBase List > 1-METHYL-3,3-DIPHENYLPROPYLAMINE

1-METHYL-3,3-DIPHENYLPROPYLAMINE

Product Name
1-METHYL-3,3-DIPHENYLPROPYLAMINE
CAS No.
15793-40-5
Chemical Name
1-METHYL-3,3-DIPHENYLPROPYLAMINE
Synonyms
Bicor;Terodiline;Terodilina;Terodilinum;RARECHEM AN KC 0196;Terodilinum [inn-latin];Terodiline [inn:ban:jan];Terodilina [inn-spanish];7082-21-5 (Hydrochloride);4,4-diphenyl-2-butanamine
CBNumber
CB1411780
Molecular Formula
C20H27N
Formula Weight
281.44
MOL File
15793-40-5.mol
More
Less

1-METHYL-3,3-DIPHENYLPROPYLAMINE Property

Melting point:
<25 °C
Boiling point:
bp1.0 130-132°
Density 
0.956±0.06 g/cm3(Predicted)
pka
10.47±0.38(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

AHH
Product number
MT-17814
Product name
1-Methyl-3,3-diphenylpropylamine
Purity
98%
Packaging
10g
Price
$480
Updated
2021/12/16
More
Less

1-METHYL-3,3-DIPHENYLPROPYLAMINE Chemical Properties,Usage,Production

Uses

Terodiline, an antispasmodic agent, blocks hERG current with the IC50 of 375 nM.?Terodiline has both anticholinergic and calcium antagonist properties, and effectively reduces abnormal bladder contractions caused by detrusor instability.?Terodiline can be used for the research of urinary incontinence[1][2].

brand name

Mictrol;Micturin;Mitrol;Miucurin;Terolin.

World Health Organization (WHO)

Terodiline, an anticholinergic and calcium-channel blocking agent, was first introduced into medicine in the mid 1960s for the treatment of angina pectoris. In 1986, it was registered for the indication of urinary incontinence. In 1991, its use in urinary incontinence was reported to be associated with severe cardiac arrhythmias. This led to a temporary withdrawal in a few Member States in 1991, followed by a final withdrawal by the manufacturer in 1992.

in vivo

Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg)[1].

Animal Model:Fmale or male Hartley guinea pigs (200-600 g)[1]
Dosage:80 mg/kg
Administration:Administered S.C.
Result:Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal.

References

[1] Ruth L Martin, et al. In vitro preclinical cardiac assessment of tolterodine and terodiline: multiple factors predict the clinical experience. J Cardiovasc Pharmacol.?2006 Nov;48(5):199-206. DOI:10.1097/01.fjc.0000246853.15926.d4
[2] H D Langtry, et al. Terodiline. A review of its pharmacological properties, and therapeutic use in the treatment of urinary incontinence. Drugs.?1990 Nov;40(5):748-61. DOI:10.2165/00003495-199040050-00008

1-METHYL-3,3-DIPHENYLPROPYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-METHYL-3,3-DIPHENYLPROPYLAMINE Suppliers

China 9 Germany 1 United Kingdom 4 United States 3 Global 17
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 18100677375
Email
sales@szzxbio.com
Country
China
ProdList
2993
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
Advantage
58
Shaanxi Didu New Materials Co. Ltd
Tel
+86-89586680 +86-13289823923
Email
1026@dideu.com
Country
China
ProdList
9080
Advantage
58

15793-40-5, 1-METHYL-3,3-DIPHENYLPROPYLAMINERelated Search:

3,3-Diphenylpropylamine N-METHYL-3,3-DIPHENYLPROPYLAMINE

  • Benzenepropanamine, N-(1,1-dimethylethyl)-alpha-methyl-gamma-phenyl-
  • Bicor
  • N-(tert-Butyl)-4,4-diphenyl-2-butanamine
  • N-tert-Butyl-1-methyl-3,3-diphenylpropylamine
  • Propylamine, N-tert-butyl-1-methyl-3,3-diphenyl-
  • Terodiline
  • N-tert-Butyl-α-methyl-γ-phenylbenzenepropan-1-amine
  • 7082-21-5 (Hydrochloride)
  • Terodilina
  • Terodilina [inn-spanish]
  • Terodiline [inn:ban:jan]
  • Terodilinum
  • Terodilinum [inn-latin]
  • 1-METHYL-3,3-DIPHENYLPROPYLAMINE
  • RARECHEM AN KC 0196
  • N-tert-butyl-4,4-diphenylbutan-2-amine
  • 4,4-diphenyl-2-butanamine
  • Benzenepropanamine, N-(1,1-dimethylethyl)-α-methyl-γ-phenyl-
  • 15793-40-5