2,4-DI-PIPERIDIN-1-YL-PHENYLAMINE
- Product Name
- 2,4-DI-PIPERIDIN-1-YL-PHENYLAMINE
- CAS No.
- 436096-88-7
- Chemical Name
- 2,4-DI-PIPERIDIN-1-YL-PHENYLAMINE
- Synonyms
- Dipiperidino-(2,4)-anilin;2,4-Di(piperidin-1-yl)aniline;2,4-DI-PIPERIDIN-1-YL-PHENYLAMINE;Benzenamine, 2,4-di-1-piperidinyl-
- CBNumber
- CB1417777
- Molecular Formula
- C16H25N3
- Formula Weight
- 259.39
- MOL File
- Mol file
2,4-DI-PIPERIDIN-1-YL-PHENYLAMINE Property
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 008577
- Product name
- 2,4-Di-piperidin-1-yl-phenylamine
- Packaging
- 1g
- Price
- $378
- Updated
- 2021/12/16
- Product number
- CHM0089050
- Product name
- 2,4-DI-PIPERIDIN-1-YL-PHENYLAMINE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $762.3
- Updated
- 2021/12/16
- Product number
- 9433CC
- Product name
- 2,4-Di-piperidin-1-yl-phenylamine
- Packaging
- 10g
- Price
- $1616
- Updated
- 2021/12/16
- Product number
- CM252954
- Product name
- 2,4-Di(piperidin-1-yl)aniline
- Purity
- 97%
- Packaging
- 10g
- Price
- $1047
- Updated
- 2021/12/16
- Product number
- CD11123989
- Product name
- 2,4-Di(piperidin-1-yl)aniline
- Purity
- 97%
- Packaging
- 10g
- Price
- $1109
- Updated
- 2021/12/16
2,4-DI-PIPERIDIN-1-YL-PHENYLAMINE Chemical Properties,Usage,Production
Synthesis
53013-41-5
436096-88-7
Example 23 5-(N-hydroxyformamidinyl)-furan-2-carboxylic acid (2,4-di-piperidin-1-yl-phenyl)-amide was synthesized as follows: a) Preparation of S-cyano-furan-1-carboxylic acid (2,4-di-piperidin-1-yl-phenyl)-amide: Piperidine (3.35 g, 39.4 mmol) was added dropwise to a solution of 2,4-difluoronitrobenzene (2.09 g, 13.1 mmol) in ethanol (10 mL) at room temperature. The reaction mixture was stirred overnight and then concentrated under vacuum. The residue was dissolved in ethyl acetate (100 mL), washed with water (2 x 100 mL), dried over anhydrous sodium sulfate and concentrated again under vacuum. Purification by silica gel column chromatography (10% ethyl acetate-hexane) gave 610 mg (16% yield) of 2,4-dipiperidinyl nitrobenzene as an oil. Subsequently, 2,4-dipiperidinylnitrobenzene (273 mg, 0.94 mmol) was stirred in methanol (10 mL) in the presence of 5% Pd-C (168 mg) under hydrogen atmosphere for 2 hours. The reaction mixture was filtered through diatomaceous earth and concentrated in vacuum to give 230 mg (94% yield) of 2,4-dipiperidinylaniline as an oil. Using a method similar to step (c) of Example 4, 2,4-dipiperidinylaminobenzene (100 mg, 0.38 mmol) was reacted with 5-cyanofuran-2-carbonyl chloride (73 mg, 0.46 mmol) in the presence of N,N-diisopropylethylamine (DIEA, 145 μL, 0.83 mmol) to give 90 mg (62% yield) of 2,4 -bis(piperidin-1-yl)aniline as a yellow solid. Mass spectrum (ESI, m/z): calculated value of C22H26N4O2 was 379.2 (M + H) and measured value was 379.2.
References
[1] Patent: WO2006/47504, 2006, A1. Location in patent: Page/Page column 68-69
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 5, p. 1642 - 1648
2,4-DI-PIPERIDIN-1-YL-PHENYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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