ChemicalBook > CAS DataBase List > 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE

1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE

Product Name
1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE
CAS No.
80360-20-9
Chemical Name
1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE
Synonyms
NSC 628191;BUTTPARK 98 4-06;BUTTPARK 98\04-06;1-(Phenylsulfonyl)-3-formylindole;3-Formyl-1-(phenylsulphonyl)-1H-indole;1-(Phenylsulfonyl)indole-3-carbaldehyde;1-PHENYLSULPHONYLINDOLE-3-CARBOXALDEHYDE;1-(PHENYLSULFONYL)-3-INDOLECARBOXALDEHY&;1-(PHENYLSULFONYL)-3-INDOLECARBOXALDEHYDE;1-(Benzenesulfonyl)indole-3-carboxaldehyde
CBNumber
CB1422285
Molecular Formula
C15H11NO3S
Formula Weight
285.32
MOL File
80360-20-9.mol
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1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE Property

Melting point:
157-161 °C(lit.)
Boiling point:
513.6±42.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
Appearance
Light yellow to brown Solid
CAS DataBase Reference
80360-20-9
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
Y4131
Product name
1-(Phenylsulfonyl)-1H-indole-3-carbaldehyde
Packaging
100mg
Price
$89
Updated
2021/12/16
SynQuest Laboratories
Product number
8H69-1-0C
Product name
1-(Phenylsulfonyl)-1H-indole-3-carboxaldehyde
Purity
97%
Packaging
1g
Price
$96
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0016975
Product name
1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE
Purity
95.00%
Packaging
1G
Price
$631.85
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0016975
Product name
1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE
Purity
95.00%
Packaging
10G
Price
$1252.78
Updated
2021/12/16
Ambeed
Product number
A276671
Product name
1-(Phenylsulfonyl)-1H-indole-3-carbaldehyde
Purity
97%
Packaging
100mg
Price
$22
Updated
2021/12/16
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1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE Chemical Properties,Usage,Production

Synthesis

487-89-8

98-09-9

80360-20-9

GENERAL STEPS: NaH (60% dispersed in mineral oil, 40.00 mmol, 0.96 g) was added in batches to a stirred solution of 3-indolecarboxaldehyde (20.00 mmol, 2.90 g) in anhydrous THF (50 mL) under ice bath cooling conditions. After slowly warming to room temperature, stirring was continued for 30 min. Subsequently, anhydrous THF solution of benzenesulfonyl chloride (24.00 mmol, 4.24 g) was added dropwise. The progress of the reaction was monitored by TLC and after complete disappearance of the raw material 3-indolecarboxaldehyde, the solvent was removed by evaporation under reduced pressure. The reaction mixture was diluted with ice water (300 mL) and the solid product was collected by filtration. Recrystallization with acetone/petroleum ether (60-90 °C) afforded the target product 1-(phenylsulfonyl)-3-indolecarboxaldehyde in 97% yield, melting point 151-153 °C. 1H NMR (600 MHz, CDCl3): δ 7.37 (t, J = 7.2 Hz, 1H), 7.42 (dd, J = 11.4, 4.2 Hz, 1H), 7.52 (t, J = 7.8 Hz, 2H), 7.62 (t, J = 7.2 Hz, 1H), 7.97 (t, J = 7.8 Hz, 3H), 8.20-8.31 (m, 2H), 10.11 (s, 1H). HRMS (MALDI): m/z 286.0515. calculated value C15H11NO3S: [M + H]+ 286.0538.

References

[1] Synlett, 1999, # 6, p. 786 - 788
[2] European Journal of Medicinal Chemistry, 2012, vol. 53, p. 283 - 291
[3] Journal of Organic Chemistry, 2002, vol. 67, # 3, p. 1001 - 1003
[4] Synthetic Communications, 2007, vol. 37, # 5, p. 829 - 837
[5] Tetrahedron, 1998, vol. 54, # 46, p. 13915 - 13928

1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE Suppliers

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80360-20-9, 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDERelated Search:

Indole-3-carboxaldehyde 1-(PHENYLSULFONYL)-1H-INDOLE-2-CARBALDEHYDE 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBONYL CHLORIDE 1-[(4-METHYLPHENYL)SULFONYL]-1H-INDOLE-3-CARBALDEHYDE 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE 3-ACETYL-1-(PHENYLSULFONYL)INDOLE 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXYLIC ACID RARECHEM AL BF 0453 6-CHLORO-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXAMIDE RARECHEM AL BI 1326 METHYL 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXYLATE 1-(4-METHYL-3-NITRO-BENZENESULFONYL)-1H-INDOLE-3-CARBALDEHYDE 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXAMIDE 5-CHLORO-1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXAMIDE RARECHEM AL BE 0453 METHYL 1-[(4-FLUOROPHENYL)SULFONYL]-1H-INDOLE-3-CARBOXYLATE 1-(3-NITRO-BENZENESULFONYL)-1H-INDOLE-3-CARBALDEHYDE METHYL 1-[(4-METHOXYPHENYL)SULFONYL]-1H-INDOLE-3-CARBOXYLATE

  • 1-PHENYLSULPHONYLINDOLE-3-CARBOXALDEHYDE
  • 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBALDEHYDE
  • 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXALDEHYDE
  • 1-(PHENYLSULFONYL)-3-INDOLECARBOXALDEHYDE
  • 1-BENZENESULFONYL-1 H-INDOLE-3-CARBALDEHYDE
  • BUTTPARK 98\04-06
  • 3-Formyl-1-(phenylsulphonyl)-1H-indole
  • 1-(Benzenesulfonyl)indole-3-carboxaldehyde
  • 1-(Phenylsulfonyl)-3-formylindole
  • NSC 628191
  • 1-benzenesulfonyl-1H-indole-3-carboxaldehyde
  • BUTTPARK 98 4-06
  • 1-(phenylsulphonyl)-1H-indole-3-carboxaldehyde
  • 1-(PHENYLSULFONYL)-3-INDOLECARBOXALDEHY&
  • 1H-Indole-3-carboxaldehyde, 1-(phenylsulfonyl)-
  • 1-(Phenylsulfonyl)indole-3-carbaldehyde
  • 1-(Phenylsulfonyl)-1H-indole-3-carbaldehyde - [P93839]
  • 80360-20-9
  • C15H11NO3S
  • ALDEHYDE
  • Building Blocks
  • Indoles
  • Heterocyclic Building Blocks
  • Building Blocks
  • Heterocyclic Building Blocks
  • Indoles