1,1-dioxo-N-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine

Product Name: 1,1-dioxo-N-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine
CAS No.: 874590-32-6
Chemical Name: 1,1-dioxo-N-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine
Synonyms: M1001;M1001, 10 mM in DMSO;1,1-dioxo-N-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine;3-((2-(Pyrrolidin-1-yl)phenyl)amino)benzo[d]isothiazole 1,1-dioxide;1,2-Benzisothiazol-3-amine, N-[2-(1-pyrrolidinyl)phenyl]-, 1,1-dioxide;786-O,HIF/HIF Prolyl-Hydroxylase,inhibit,HIF-PH,M-1001,Hypoxia-inducible factors,HIFs,chronic kidney disease,M1001,Inhibitor,HEK293T,M 1001
CBNumber: CB14278239
Molecular Formula: C17H17N3O2S
Formula Weight: 327.4
MOL File: 874590-32-6.mol

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1,1-dioxo-N-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine Property

Boiling point:: 526.1±52.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (763.59 mM; Need ultrasonic)
form: A solid
pka: 5.38±0.40(Predicted)
color: Light green to green

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0087092
Product name: M1001
Purity: 99.77%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0087092
Product name: M1001
Purity: 99.77%
Packaging: 10mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0087092
Product name: M1001
Purity: 99.77%
Packaging: 25mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-0087092
Product name: M1001
Purity: 99.77%
Packaging: 50mg
Price: $990
Updated: 2021/12/16

ChemScene

Product number: CS-0087092
Product name: M1001
Purity: 99.77%
Packaging: 100mg
Price: $1650
Updated: 2021/12/16

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1,1-dioxo-N-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine Chemical Properties,Usage,Production

Uses

M1001 is a weak hypoxia-inducible factor-2α (HIF-2α) agonist. M1001 can bind to the HIF-2α PAS-B domain, with a Kd of 667 nM. M1001 can be used in chronic kidney disease research[1].

References

[1] Wu D, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Feb 25. DOI:10.1038/s41589-019-0234-5

1,1-dioxo-N-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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1,1-dioxo-N-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine Suppliers

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874590-32-6, 1,1-dioxo-N-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amineRelated Search:

1,1-dioxo-N-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine

M1001

3-((2-(Pyrrolidin-1-yl)phenyl)amino)benzo[d]isothiazole 1,1-dioxide

786-O,HIF/HIF Prolyl-Hydroxylase,inhibit,HIF-PH,M-1001,Hypoxia-inducible factors,HIFs,chronic kidney disease,M1001,Inhibitor,HEK293T,M 1001

1,2-Benzisothiazol-3-amine, N-[2-(1-pyrrolidinyl)phenyl]-, 1,1-dioxide

M1001, 10 mM in DMSO

874590-32-6