17β-Estradiol 3-O-Sulfate SodiuM Salt Property

Melting point:

207 °C

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-40

Safety Statements 

22-36

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

17β-Estradiol 3-O-Sulfate SodiuM Salt Chemical Properties,Usage,Production

Uses

β-Estradiol 3-sulfate sodium salt has been used to measure the estradiol level from culture supernatant in ultra-performance liquid chromatography-tandem mass spectrometry.

Uses

17β-Estradiol 3-O-Sulfate Sodium Salt is a neuroactive steroid used in the studies of human recombinant p1 γ-aminobutyric acid type C (GABAC) recptors.

General Description

β-Estradiol is secreted by developing ovaries and is predominant during premenopause in women.

Biochem/physiol Actions

β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity. β-Estradiol maintains bone homeostasis, hence it is preferred for osteoporosis therapy. 17-β-Estradiol is the most active estrogen generated in our body. During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.