(+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL
- Product Name
- (+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL
- CAS No.
- 256934-39-1
- Chemical Name
- (+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL
- Synonyms
- HU-308;4-[4-(1,1-Dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol;[(1S,2S,5S)-2-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-6,6-dimethyl-4-bicyclo[3.1.1]hept-3-enyl]methanol;(+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL;(+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL;Bicyclo[3.1.1]hept-2-ene-2-methanol, 4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethyl-, (1S,4S,5S)-;(1R,4R,5R)-rel-(+)-4-[4-(1,1-DiMethylheptyl)-2,6-diMethoxyphenyl]-6,6-diMethylbicyclo[3.1.1]hept-2-ene-2-Methanol;Bicyclo[3.1.1]hept-2-ene-2-methanol, 4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethyl-, (1R,4R,5R)-rel-(+)-
- CBNumber
- CB1438149
- Molecular Formula
- C27H42O3
- Formula Weight
- 414.62
- MOL File
- 256934-39-1.mol
(+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL Property
- Boiling point:
- 508.7±50.0 °C(Predicted)
- Density
- 0.999
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- solution in methyl acetate
- pka
- 14.77±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
H336May cause drowsiness or dizziness
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 90086
- Product name
- HU-308
- Purity
- >98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 90086
- Product name
- HU-308
- Purity
- >98%
- Packaging
- 5mg
- Price
- $151
- Updated
- 2024/03/01
- Product number
- 90086
- Product name
- HU-308
- Purity
- >98%
- Packaging
- 10mg
- Price
- $266
- Updated
- 2024/03/01
- Product number
- 90086
- Product name
- HU-308
- Purity
- >98%
- Packaging
- 25mg
- Price
- $573
- Updated
- 2024/03/01
- Product number
- 3088
- Product name
- HU308
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $289
- Updated
- 2021/12/16
(+/-)-4R-[4-(1,1-DIMETHYLHEPTYL)-2,6-DIMETHOXYPHENYL]-6,6-DIMETHYL-1R,5R-BICYCLO[3.1.1]HEPT-2-ENE-2-METHANOL Chemical Properties,Usage,Production
Uses
A specific CB2-specific agonist that inhibits forskolin-stimulated cAMP production in CB2-transfected cells. It reduces blood pressure, blocks defecation, and elicits anti-inflammatory and peripheral analgesic activity and thus may lead to new therapies for hypertension, inflammation, and pain. Controlled Substance.
Definition
ChEBI: HU-308 is a carbobicyclic compound that is bicyclo[3.1.1]hept-2-ene which is substituted by a hydroxymethyl group at position 2, a 2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl group at position 4, and two methyl groups at position 6 (the 1S,4S,5S stereoisomer). A highly selective and effective cannabinoid type-2 agonist and the enantiomer of HU-433. It has a role as a CB2 receptor agonist, an anti-inflammatory agent, a bone density conservation agent, an apoptosis inhibitor and an antihypertensive agent. It is a bridged compound, a carbobicyclic compound, an aromatic ether, a synthetic cannabinoid and a primary allylic alcohol.
Biological Activity
Potent and selective CB 2 receptor agonist (K i values are 22.7 nM and > 10 μ M for CB 2 and CB 1 receptors respectively, EC 50 = 5.57 nM). Displays antiallodynic activity in the rat hindpaw incision model of postoperative pain.
storage
Store at -20°C