CHOLINE THIEOPHYLLINATE

Product Name: CHOLINE THIEOPHYLLINATE
CAS No.: 4499-40-5
Chemical Name: CHOLINE THIEOPHYLLINATE
Synonyms: Sabidal;Teovent;filoral;choledyl;cholegyl;Zy-15061;teokolin;Bronchodil;Sabidal SR;theoxylline
CBNumber: CB1441097
Molecular Formula: C12H21N5O3
Formula Weight: 283.33
MOL File: 4499-40-5.mol

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CHOLINE THIEOPHYLLINATE Property

Melting point:: 176-178 °C
storage temp.: Store at -20°C
solubility: PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
color: White to off-white

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Safety

HS Code: 2939590000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1484009
Product name: Oxtriphylline
Packaging: 500mg
Price: $250
Updated: 2024/03/01

Cayman Chemical

Product number: 24006
Product name: Oxtriphylline
Purity: ≥98%
Packaging: 50mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 24006
Product name: Oxtriphylline
Purity: ≥98%
Packaging: 100mg
Price: $108
Updated: 2024/03/01

Cayman Chemical

Product number: 24006
Product name: Oxtriphylline
Purity: ≥98%
Packaging: 500mg
Price: $505
Updated: 2024/03/01

TRC

Product number: O867275
Product name: Oxytrimethylline
Packaging: 500mg
Price: $160
Updated: 2021/12/16

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CHOLINE THIEOPHYLLINATE Chemical Properties,Usage,Production

Originator

Sabidal ,S.R. Zyma, UK ,1983

Uses

Bronchodilator.

Uses

Oxytrimethylline is used in the treatment for chronic asthma.

Manufacturing Process

18 parts by weight of theophylline are added to 37.8 parts by weight of aqueous choline bicarbonate (47% assay) and the mixture stirred and heated at 80°C to 90°C until the evolution of carbon dioxide has ceased and complete solution effected. Water is separated from the reaction mixture by distillation under a vacuum sufficient to keep the still temperature between 50°C and 55 C. After about 95 parts by weight of water have been separated, about 80 parts by weight of isopropyl alcohol are added and the mixture subjected to further distillation under a vacuum sufficient to keep the mixture boiling at about 40°C. The distillation removes some of the water as an azeotrope with the isopropyl alcohol. During the removal of the water-isopropyl alcohol azeotrope a crystalline precipitate forms. The mixture is further cooled slowly to 5°C and the crystalline precipitate filtered off. The choline theophyllinate crystals are then washed with isopropyl alcohol and dried under vacuum at about 70°C. A second crop of the product may be obtained from the mother liquor by further reduction in volume and cooling. A yield of 90.5% of theory of choline theophyllinate is obtained completely free of inorganic salts.

brand name

Choledyl(Parke-Davis).

Therapeutic Function

Smooth muscle relaxant

CHOLINE THIEOPHYLLINATE Preparation Products And Raw materials

Raw materials

Choline hydroxide Theophylline

Preparation Products

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CHOLINE THIEOPHYLLINATE Suppliers

Canada 1 China 41 Europe 2 India 7 United Kingdom 1 United States 14 Global 66

Youhua Pharmaceutical (Leshan) Co., Ltd.

Tel: 0833-2595508
Email: 2824272261@qq.com
Country: China
ProdList: 5
Advantage: 58

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8836
Advantage: 52

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2866
Advantage: 58

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3120
Advantage: 55

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973186 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 18338
Advantage: 68

Wuhan Wsem Biological Co., Ltd.

Tel: 027-83778876 13667159345
Fax: 027-83778876
Email: 13667159345@163.com
Country: China
ProdList: 1997
Advantage: 55

JinJin Le Chemical Co., Ltd

Tel: 10106090
Email: jjlchem2@163.com
Country: China
ProdList: 9981
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

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View Lastest Price from CHOLINE THIEOPHYLLINATE manufacturers

Qiuxian Baitai New Material Co., LTD

Product: CHOLINE THIEOPHYLLINATE 4499-40-5
Price: US $8.00/g
Min. Order: 1KG
Purity: 99%
Supply Ability: 5ton/Month
Release date: 2021-11-26

Dideu Industries Group Limited

Product: CHOLINE THIEOPHYLLINATE 4499-40-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-05-28

Career Henan Chemical Co

Product: CHOLINE THIEOPHYLLINATE 4499-40-5
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

4499-40-5, CHOLINE THIEOPHYLLINATERelated Search:

CLENBUTEROL Aminophylline Diprophylline Histamine Choline chloride Kallikrein Pentoxifylline Ketotifen fumarate Carmofur 6-Mercaptopurine Azathioprine 5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol Nifedipine 1-(2,6-Dimethylphenoxy)-2-propanamine CHOLINE Choline hydroxide Pamabrom CHOLINE THIEOPHYLLINATE

theophyllinecholinate

theophyllinesaltofcholine

choledyl

choledylsa400

cholegyl

choline,compd.withtheophylline(1:1)

cholinetheophyllinesalt

cholinophylline

ethanaminium,2-hydroxy-n,n,n-trimethyl-,saltwith3,7-dihydro-1,3-dimethyl-1h

2-hydroxy-N,N,N-trimethylethanaminium 1,3-dimethyl-2-oxo-2,3-dihydro-1H-purin-6-olate

Bronchodil

choline theophylline

Sabidal SR

CalcliumTheophylineate

theoxylline

Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (1:1)

OXTRIPHYLLINE,USP

Sabidal

Teovent

Zy-15061

Oxtriphylline (500 mg)

2-Hydroxy-N,N,N-trimethylethanaminium salt with 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione

1,3-dimethyl-2-oxopurin-6-olate,2-hydroxyethyl(trimethyl)azanium

OXTRIPHYLLINE

(2-hydroxyethyl)trimethylammoniumcompoundwiththeophylline

ethanaminium,2-hydroxy-n,n,n-trimethyl-,saltwith3,7-dihydro-1,3-dimethylp

filoral

oxtrimethylline

-purine-2,6-dione(1:1)

soliphylline

teofilcolina

teokolin

RLANKEDHRWMNRO-UHFFFAOYSA-M

Oxytrimethylline

CHOLINE THIEOPHYLLINATE

ChOIiniTheophyllinas

CHOLINE THIEOPHYLLINATE USP/EP/BP

Oxtriphylline (1484009)

Oxtriphylline (Choline theophyllinate)

c h oli ne Th e oph ylli na te i s c h oli ne 1,2,3,6-te tra h yd ro-1,3-d i me th yl-2,6-d i oxo-7h -puri n-7-i d e . i t c onta i ns not le ss th a n 41.9% a nd not more th a n 43.6% of c h oli ne , c 5h 15NO2, a nd not le ss th a n 61.7% a nd not more th a n 65.5% of th e oph ylli ne , c 7h 9N4O2, e a c h c a lc ula te d wi th re f e re nc e to th e d ri e d sub sta nc e

Cholintheophyllinat

4499-40-5

C7H7N4O2C5H14NO

API