ChemicalBook > CAS DataBase List > 3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE

3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE

Product Name
3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE
CAS No.
14008-79-8
Chemical Name
3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE
Synonyms
FC-1;SL6057;Wy 2149;3 CPMT,3CPMT;Chlortropbenzyl hydrochloride;4μ-Chloro-3α-(diphenylmethoxy)tropane hydrochloride;3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE;3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane hydrochloride
CBNumber
CB1445929
Molecular Formula
C21H25Cl2NO
Formula Weight
378.34
MOL File
14008-79-8.mol
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3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE Property

storage temp. 
−20°C
solubility 
H2O: 6.3 mg/mL
form 
solid
color 
white
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
26-36
WGK Germany 
3
RTECS 
YM3055500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B6502
Product name
3-CPMT
Packaging
10mg
Price
$108
Updated
2021/12/16
ApexBio Technology
Product number
B6502
Product name
3-CPMT
Packaging
50mg
Price
$471
Updated
2021/12/16
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3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Clobenztropine,Onbio Inc.

Uses

3-CPMT is a high affinity dopamine transporter blocker.

Manufacturing Process

A solution of 28.2 g (0.2 mol) of 3-tropanol is prepared in 50 ml of xylol, and to this solution is added 23.8 g (0.1 mol) of 4-chlorobenzhydryl chloride. The resultant solution is heated for 7 h at 145°-155°C, following which the mixture is cooled and filtered. The clear filtrate thus obtained is washed with 50 ml of 5% aqueous potassium carbonate solution and then with three successive 25 ml portion of water. The xylol solution is then extracted with three successive 50 ml portions of 2 N hydrochloric acid. The xylol layer is discarded and the acid extracts are combined and rendered strongly basic by the addition of 22.5% aqueous potassium hydroxide, resulting in the formation of an oily base which separates and which is then extracted with
benzol, from which the benzol is evaporated to yield crude 3-(4'- chlorobenzhydryloxy)tropane as a brown oil.
2.0 g of 3-(4'-chlorobenzhydryloxy)tropane is treated with 10 ml of 4.5 N isopropanoic acid hydrogen chloride solution, and the pasty mixture which results is diluted with approximately 30 ml of absolute ether. A solid product is formed which is separated by filtration and then washed with absolute ether. The product is then purified by dissolving it in hot isopropanol, followed by clarification with activated charcoal. Upon cooling the filtrate, the 3-(4'- chlorophenylbenzyloxy)tropane separates as a crystalline powder, melting point 215°-217°C.
In practice it is usually used as hydrochloride.

Therapeutic Function

Antihistaminic

3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE Suppliers

14008-79-8, 3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDERelated Search:


  • 3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE
  • 4μ-Chloro-3α-(diphenylmethoxy)tropane hydrochloride
  • Wy 2149
  • 3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane hydrochloride
  • Chlortropbenzyl hydrochloride
  • FC-1
  • SL6057
  • 3 CPMT,3CPMT
  • 14008-79-8
  • C21H24ClNOHCl
  • C21H24ClNOClH