5-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID

5-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID Property

Melting point:

206-208 °C (decomp)

Boiling point:

452.3±33.0 °C(Predicted)

Density 

1.285±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

4.45±0.10(Predicted)

Appearance

Off-white to pale purple Solid

Safety

Hazard Codes 

Xi,Xn

Risk Statements 

22

HazardClass 

IRRITANT

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

5-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

5-Phenylpyrrole-2-carboxylate (20 mg, 0.09 mmol) was dissolved in a solvent mixture of 1 mL of tetrahydrofuran, 0.5 mL of methanol and 0.5 mL of water. After stirring at room temperature, LiOH (4 mg, 0.18 mmol) was added. Stirring was continued at room temperature for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming that the reaction was complete, the solvent was removed using a rotary evaporator. Ice water was added to the reaction residue, which was then acidified with 1 M HCl solution to the appropriate pH and the precipitate was collected by filtration to afford 5-phenyl-1H-pyrrole-2-carboxylic acid (10 mg, 59% yield).

References

[1] Patent: CN107151255, 2017, A. Location in patent: Paragraph 0244; 0245; 0246
[2] Magnetic Resonance in Chemistry, 2009, vol. 47, # 12, p. 1101 - 1109