FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

Product Name: FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
CAS No.: 884880-39-1
Chemical Name: FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
Synonyms: N-Fmoc-3-hydroxy-D-valine;Fmoc-3-Methyl-D-threonine;(R)-N-Fmoc-β-Hydroxyvaline;(R)-Fmoc-b,b-dimethyl-serine;(R)-Fmoc-β-hydroxy-valine≥ 99% (HPLC);FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID;(R)-2-(Fmoc-amino)-3-hydroxy-3-methylbutanoic Acid;(R)-N-Fmoc-2-amino-3-hydroxy-3-methylbutanoic acid;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-hydroxy-D-valine;D-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-hydroxy-
CBNumber: CB1456358
Molecular Formula: C20H21NO5
Formula Weight: 355.38
MOL File: Mol file

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FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Property

storage temp.: 2-8°C
Appearance: White to off-white Solid
optical activity: 7.433°(C=0.504g/100mL, CHCL3, 20°C, 589nm)

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Activate Scientific

Product number: AS111375
Product name: (R)-2-Fmoc-amino-3-hydroxy-3-methylbutanoic acid
Purity: 97% ee
Packaging: 100mg
Price: $222
Updated: 2021/12/16

Matrix Scientific

Product number: 042098
Product name: Fmoc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
Packaging: 100mg
Price: $268
Updated: 2021/12/16

Activate Scientific

Product number: AS111375
Product name: (R)-2-Fmoc-amino-3-hydroxy-3-methylbutanoic acid
Purity: 97% ee
Packaging: 250mg
Price: $337
Updated: 2021/12/16

Activate Scientific

Product number: AS111375
Product name: (R)-2-Fmoc-amino-3-hydroxy-3-methylbutanoic acid
Purity: 97% ee
Packaging: 1g
Price: $767
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0004363
Product name: FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
Purity: 95.00%
Packaging: 100MG
Price: $872.03
Updated: 2021/12/16

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FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Chemical Properties,Usage,Production

Chemical Properties

White powder

Synthesis

82911-69-1

288159-40-0

884880-39-1

GENERAL STEPS: (R)-N-Fmoc-2-amino-3-hydroxy-3-methylbutanoic acid was synthesized in the following steps: first, (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid was stripped of the Boc protecting group in a 1:1 trifluoroacetic acid/dichloromethane solution. Subsequently, the Fmoc protection reaction was carried out using 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu) and sodium bicarbonate (NaHCO3) in aqueous acetone solution. After completion of the reaction, the product was purified by silica gel column chromatography (eluent ratio of 1:1:98 methanol/acetic acid/chloroform). Finally, the purified product was freeze-dried from aqueous acetonitrile solution to afford the target compound in 78% yield.

References

[1] Patent: US2009/48161, 2009, A1. Location in patent: Page/Page column 40

FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Suppliers

China 32 India 1 United States 5 Global 38

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884880-39-1, FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACIDRelated Search:

(R)-2-Amino-3-hydroxy-3-methylbutanoic acid

FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

(R)-Fmoc-b,b-dimethyl-serine

(R)-Fmoc-β-hydroxy-valine≥ 99% (HPLC)

(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-hydroxy-3-methylbutanoic acid

D-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-hydroxy-

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-hydroxy-D-valine

(R)-N-Fmoc-2-amino-3-hydroxy-3-methylbutanoic acid

(R)-N-Fmoc-β-Hydroxyvaline

Fmoc-3-Methyl-D-threonine

N-Fmoc-3-hydroxy-D-valine

(R)-2-(Fmoc-amino)-3-hydroxy-3-methylbutanoic Acid

884880-39-1

unnatural amino acids