FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
- Product Name
- FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
- CAS No.
- 884880-39-1
- Chemical Name
- FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
- Synonyms
- N-Fmoc-3-hydroxy-D-valine;Fmoc-3-Methyl-D-threonine;(R)-N-Fmoc-β-Hydroxyvaline;(R)-Fmoc-b,b-dimethyl-serine;(R)-Fmoc-β-hydroxy-valine≥ 99% (HPLC);FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID;(R)-2-(Fmoc-amino)-3-hydroxy-3-methylbutanoic Acid;(R)-N-Fmoc-2-amino-3-hydroxy-3-methylbutanoic acid;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-hydroxy-D-valine;D-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-hydroxy-
- CBNumber
- CB1456358
- Molecular Formula
- C20H21NO5
- Formula Weight
- 355.38
- MOL File
- Mol file
FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Property
- storage temp.
- 2-8°C
- Appearance
- White to off-white Solid
- optical activity
- 7.433°(C=0.504g/100mL, CHCL3, 20°C, 589nm)
Safety
- HazardClass
- IRRITANT
N-Bromosuccinimide Price
- Product number
- AS111375
- Product name
- (R)-2-Fmoc-amino-3-hydroxy-3-methylbutanoic acid
- Purity
- 97% ee
- Packaging
- 100mg
- Price
- $222
- Updated
- 2021/12/16
- Product number
- 042098
- Product name
- Fmoc-(R)-2-amino-3-hydroxy-3-methylbutanoic acid
- Packaging
- 100mg
- Price
- $268
- Updated
- 2021/12/16
- Product number
- AS111375
- Product name
- (R)-2-Fmoc-amino-3-hydroxy-3-methylbutanoic acid
- Purity
- 97% ee
- Packaging
- 250mg
- Price
- $337
- Updated
- 2021/12/16
- Product number
- AS111375
- Product name
- (R)-2-Fmoc-amino-3-hydroxy-3-methylbutanoic acid
- Purity
- 97% ee
- Packaging
- 1g
- Price
- $767
- Updated
- 2021/12/16
- Product number
- AAA0004363
- Product name
- FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $872.03
- Updated
- 2021/12/16
FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Chemical Properties,Usage,Production
Chemical Properties
White powder
Synthesis
82911-69-1
288159-40-0
884880-39-1
GENERAL STEPS: (R)-N-Fmoc-2-amino-3-hydroxy-3-methylbutanoic acid was synthesized in the following steps: first, (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid was stripped of the Boc protecting group in a 1:1 trifluoroacetic acid/dichloromethane solution. Subsequently, the Fmoc protection reaction was carried out using 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu) and sodium bicarbonate (NaHCO3) in aqueous acetone solution. After completion of the reaction, the product was purified by silica gel column chromatography (eluent ratio of 1:1:98 methanol/acetic acid/chloroform). Finally, the purified product was freeze-dried from aqueous acetonitrile solution to afford the target compound in 78% yield.
References
[1] Patent: US2009/48161, 2009, A1. Location in patent: Page/Page column 40
FMOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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