QX77
- Product Name
- QX77
- CAS No.
- 1798331-92-6
- Chemical Name
- QX77
- Synonyms
- QX77;CMA activator;CMA ACTIVATOR;QX77;QX-77;QX 77;Acetamide, N-[4-(7-chloro-2H-1,4-benzoxazin-3-yl)phenyl]-;N-(4-(7-Chloro-2H-benzo[b][1,4]oxazin-3-yl)phenyl)acetamide;LAMP2A,QX 77,Inhibitor,Rab11,QX77,inhibit,QX-77,CMA,pluripotency,MEFs,Autophagy
- CBNumber
- CB14656563
- Molecular Formula
- C16H13ClN2O2
- Formula Weight
- 300.74
- MOL File
- 1798331-92-6.mol
QX77 Property
- Boiling point:
- 514.5±50.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 25mg/mL; DMF:PBS (pH 7.2) (1:2): 0.3mg/mL; DMSO: 15mg/mL
- form
- A solid
- pka
- 14?+-.0.70(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- SML2634
- Product name
- QX77
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $101.65
- Updated
- 2025/07/31
- Product number
- SML2634
- Product name
- QX77
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $433
- Updated
- 2025/07/31
- Product number
- 29903
- Product name
- QX-77
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 29903
- Product name
- QX-77
- Packaging
- 50mg
- Price
- $721
- Updated
- 2024/03/01
- Product number
- 29903
- Product name
- QX-77
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
QX77 Chemical Properties,Usage,Production
Uses
QX77 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells[1]. QX77 can impede self-renewal and promote differentiation of ES cells[2].
Biological Activity
QX77 is a chaperone-mediated autophagy (CMA) activator derived from the atypical retinoid AR7 th at activates CMA by antagonizing retinoic acid receptor-α (RARα) signaling. QX77 rescues defective trafficking & lysosomal localization of the CMA receptor LAMP2A in cystinotic Ctns-/- MEFs and CTNS-KO human proximal tubule cells (PTCs) by restoring Rab11 expression and Rab11-positive vesicles trafficking to the level seen in wild-type cells (20 μM, 48 hrs). CMA activation by QX77 treatment (20 μM, 5 days) also significantly reduces toxic α-synuclein (α-syn) accumulation in PD patients iPSCs-derived astrocytes with LRRK2 G2019S mutation.
References
[1] Jinzhong Zhang, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 Jun 23;292(25):10328-10346 DOI:10.1074/jbc.M116.764076
[2] Yi Xu, et al. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020 Jul 24;369(6502):397-403. DOI:10.1126/science.abb4467
QX77 Preparation Products And Raw materials
Raw materials
Preparation Products
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