1R,3S-RSL 3

Product Name: 1R,3S-RSL 3
CAS No.: 1219810-13-5
Chemical Name: 1R,3S-RSL 3
Synonyms: 1R,3S-RSL 3;1R,3S RSL 3,1R,3SRSL 3;1R,3S-RSL 3, 10 mM in DMSO;1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-, methyl ester, (1R,3S)-
CBNumber: CB14662568
Molecular Formula: C23H21ClN2O5
Formula Weight: 440.88
MOL File: 1219810-13-5.mol

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1R,3S-RSL 3 Property

Boiling point:: 641.3±55.0 °C(Predicted)
Density: 1.368±0.06 g/cm3(Predicted)
pka: 16.09±0.60(Predicted)

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Hazard and Precautionary Statements (GHS)

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1R,3S-RSL 3 Chemical Properties,Usage,Production

Uses

(1R,3S)-RSL3 is the less active (1R,3S)-enantiomer of RSL3 ((1S,3R)-RSL3). (1R,3S)-RSL3 and RSL3 induce cell death in HT22 wild-type cells with EC50 values of 5.2 μM and 0.004 μM, rspectively[1].

Definition

ChEBI: (1R,3S)-2-(2-chloro-1-oxoethyl)-1-(4-methoxycarbonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylic acid methyl ester is a harmala alkaloid.

References

[1] Shin D, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018 Dec;129:454-462. DOI:10.1016/j.freeradbiomed.2018.01.019

1R,3S-RSL 3 Preparation Products And Raw materials

Raw materials

Preparation Products

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1R,3S-RSL 3 Suppliers

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1219810-13-5, 1R,3S-RSL 3Related Search:

1R,3S-RSL 3

1R,3S RSL 3,1R,3SRSL 3

1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-, methyl ester, (1R,3S)-

1R,3S-RSL 3, 10 mM in DMSO

1219810-13-5