Compound 48/80 (hydrochloride)
- Product Name
- Compound 48/80 (hydrochloride)
- CAS No.
- 848035-21-2
- Chemical Name
- Compound 48/80 (hydrochloride)
- Synonyms
- C48/80 trihydrochloride;Compound 48/80 (hydrochloride);Compound 48/80 trihydrochlorid;Compound 48/80 trihydrochloride, 10 mM in DMSO;Benzeneethanamine, 4-methoxy-3,5-bis[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-N-methyl-, hydrochloride (1:3)
- CBNumber
- CB14666319
- Molecular Formula
- C32H48Cl3N3O3
- Formula Weight
- 629.10082
- MOL File
- 848035-21-2.mol
Compound 48/80 (hydrochloride) Property
- storage temp.
- Store at -20°C, sealed storage, away from moisture ,protect from light
- solubility
- Water: 100 mM
- form
- A solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P311Call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 22173
- Product name
- Compound 48/80 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $131
- Updated
- 2024/03/01
- Product number
- 22173
- Product name
- Compound 48/80 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $50
- Updated
- 2023/01/06
- Product number
- CS-0109325
- Product name
- Compound48/80(trihydrochloride)
- Purity
- 98.63%
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 4354EF
- Product name
- 2-[4-Methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-N-methylethanamine;trihydrochloride
- Packaging
- 100mg
- Price
- $216
- Updated
- 2021/12/16
Compound 48/80 (hydrochloride) Chemical Properties,Usage,Production
Uses
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets [1][2][3].
Biological Activity
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde condensation products. It is also a histamine releaser and mast cell degranulator. It inhibits the activity of phosphatidylinositol-specific phospholipase C in human platelets.
in vitro
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC 50 values are 2.1 μg/ml (supernatant ) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80.
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in vivo
Compound 48/80 trihydrochloride (0.75 mg/kg; ip; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter.
Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation.
| Animal Model: | 7-week-old Wistar male rats (fasted for 24 hours) |
| Dosage: | 0.75 mg/kg |
| Administration: | Intraperitoneal injection; Killed after 0.5, 3 or 6 h |
| Result: | Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin conc entrations in rats decreased time-dependently thereafter. |
References
[1] Bronner C, et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys Acta. 1987 Aug 15;920(3):301-5. DOI:10.1016/0005-2760(87)90108-1
[2] Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104. DOI:10.1371/journal.pone.0052104
[3] Kaida S, et al. Compound 48/80 causes oxidative stress in the adrenal gland of rats through mast cell degranulation. Free Radic Res. 2010 Feb;44(2):171-80. DOI:10.3109/10715760903380466
Compound 48/80 (hydrochloride) Preparation Products And Raw materials
Raw materials
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