N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE Property

Boiling point:

77-79 °C/11 mmHg (lit.)

Density 

1.362 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.464

Flash point:

89-90°C/20mm

storage temp. 

2-8°C

solubility 

Miscible with dimethoxyethane.

pka

-6.60±0.70(Predicted)

form 

Oil to Semi-Solid

color 

Colourless to Off-White

Sensitive 

Moisture Sensitive

BRN 

969956

Stability:

Hygroscopic, Moisture Sensitive

CAS DataBase Reference

677-43-0

EPA Substance Registry System

N,N-Dimethyl phosphoramidic dichloride (677-43-0)

Safety

Hazard Codes 

C

Risk Statements 

34-37

Safety Statements 

26-36/37/39

RIDADR 

UN 3265 8/PG 3

WGK Germany 

3

RTECS 

TB4025000

F 

1-3-10

HazardClass 

8

PackingGroup 

II

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE Chemical Properties,Usage,Production

Chemical Properties

Light yellow liquid

Uses

N,N-Dimethylphosphoramidodichloridate is used in the synthesis of phosphoramidates as well as (RS)-ethyl N,N-dimethylphosphoramidocyanidate (Nerve agent GA) which is used as a chemical weapon. It forms active intermediates, which react with alcohols in situ to give esters. It is also used to convert primary alcohols to alkyl chlorides. Furthe, it serves as an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. In addition to this, it reacts with 1,2 diols to prepare cyclic phosphoric amides followed by alkenes after reduction.