TP0427736

Product Name: TP0427736
CAS No.: 864374-00-5
Chemical Name: TP0427736
Synonyms: TP427736;TP-427736;TP0427736;TP0427736 HCl;TP0427736, 10 mM in DMSO;Benzothiazole, 6-[5-(4-methyl-2-thiazolyl)-1H-imidazol-4-yl]-
CBNumber: CB14667437
Molecular Formula: C14H10N4S2
Formula Weight: 298.39
MOL File: 864374-00-5.mol

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TP0427736 Property

Boiling point:: 634.7±65.0 °C(Predicted)
Density: 1.439±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 67 mg/mL (200.09 mM);Ethanol: Insoluble
pka: 9.70±0.10(Predicted)
Water Solubility: Water: Insoluble

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb573383
Product name: TP0427736 HCl
Purity: >98%
Packaging: 100mg
Price: $1060.8
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573383
Product name: TP0427736 HCl
Purity: >98%
Packaging: 250mg
Price: $2097.8
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573383
Product name: TP0427736 HCl
Purity: >98%
Packaging: 1g
Price: $4173.5
Updated: 2021/12/16

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TP0427736 Chemical Properties,Usage,Production

Biological Activity

TP0427736 is a potent ALK5 kinase inhibitor with IC50 of 2.72 nM and IC50 of 836 nM for ALK3. It also inhibits TGF-β1-induced phosphorylation of Smad2/3 in A549 cells with IC50 of 8.68 nM.

in vitro

TP0427736 can inhibit Smad2/3 phosphorylation in a concentration-dependent manner with IC50 of 8.68 nM. In outer root sheath cells, it rescued the inhibition of cell proliferation by TGF-β1 and TGF-β2.

in vivo

TP0427736 reduces hair follicle length shortening during the transition from anagen to catagen.

target

Target	Value
ALK5 (Cell-free assay)	2.72 nM

TP0427736 Preparation Products And Raw materials

Raw materials

Preparation Products

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TP0427736 Suppliers

China 20 United States 3 USA 1 Global 24

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4674
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9804
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Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32159
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
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DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
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Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
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Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
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Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

864374-00-5, TP0427736Related Search:

PTH-EPSILON-PHENYLTHIOCARBAMYL-DL-LYSINE

TP0427736

TP0427736 HCl

TP427736

TP-427736

Benzothiazole, 6-[5-(4-methyl-2-thiazolyl)-1H-imidazol-4-yl]-

TP0427736, 10 mM in DMSO

864374-00-5