TP0427736
- Product Name
- TP0427736
- CAS No.
- 864374-00-5
- Chemical Name
- TP0427736
- Synonyms
- TP427736;TP-427736;TP0427736;TP0427736 HCl;TP0427736, 10 mM in DMSO;Benzothiazole, 6-[5-(4-methyl-2-thiazolyl)-1H-imidazol-4-yl]-;6-[5-(4-Methyl-1,3-thiazol-2-yl)-1H-imidazol-4-yl]-1,3-benzothiazole
- CBNumber
- CB14667437
- Molecular Formula
- C14H10N4S2
- Formula Weight
- 298.39
- MOL File
- 864374-00-5.mol
TP0427736 Property
- Boiling point:
- 634.7±65.0 °C(Predicted)
- Density
- 1.439±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 67 mg/mL (200.09 mM);Ethanol: Insoluble
- pka
- 9.70±0.10(Predicted)
- Water Solubility
- Water: Insoluble
N-Bromosuccinimide Price
- Product number
- orb573383
- Product name
- TP0427736 HCl
- Purity
- >98%
- Packaging
- 100mg
- Price
- $1060.8
- Updated
- 2021/12/16
- Product number
- orb573383
- Product name
- TP0427736 HCl
- Purity
- >98%
- Packaging
- 250mg
- Price
- $2097.8
- Updated
- 2021/12/16
- Product number
- orb573383
- Product name
- TP0427736 HCl
- Purity
- >98%
- Packaging
- 1g
- Price
- $4173.5
- Updated
- 2021/12/16
TP0427736 Chemical Properties,Usage,Production
Uses
TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells[1].
Biological Activity
TP0427736 is a potent ALK5 kinase inhibitor with IC50 of 2.72 nM and IC50 of 836 nM for ALK3. It also inhibits TGF-β1-induced phosphorylation of Smad2/3 in A549 cells with IC50 of 8.68 nM.
in vitro
TP0427736 can inhibit Smad2/3 phosphorylation in a concentration-dependent manner with IC50 of 8.68 nM. In outer root sheath cells, it rescued the inhibition of cell proliferation by TGF-β1 and TGF-β2.
in vivo
TP0427736 reduces hair follicle length shortening during the transition from anagen to catagen.
target
| Target | Value |
| ALK5 (Cell-free assay) | 2.72 nM |
References
[1] Naruse T, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-βinduced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 Jun;69(3):485-491. DOI:10.1016/j.pharep.2017.01.024
TP0427736 Preparation Products And Raw materials
Raw materials
Preparation Products
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