MW-150
- Product Name
- MW-150
- CAS No.
- 1628502-91-9
- Chemical Name
- MW-150
- Synonyms
- MW-150;MW-150, 10 mM in DMSO;inhibit,MW 150,MW150,Autophagy,MW-150,p38 MAPK,Inhibitor;6-(4-methyl-1-piperazinyl)-3-(2-naphthalenyl)-4-(4-pyridinyl)-pyridazine;6-(4-Methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine;Pyridazine, 6-(4-methyl-1-piperazinyl)-3-(2-naphthalenyl)-4-(4-pyridinyl)-
- CBNumber
- CB14668247
- Molecular Formula
- C24H23N5
- Formula Weight
- 381.47
- MOL File
- 1628502-91-9.mol
MW-150 Property
- Boiling point:
- 606.1±55.0 °C(Predicted)
- Density
- 1.202±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 40 mg/mL (104.86 mM; Need ultrasonic)
- form
- A solid
- pka
- 7.16±0.42(Predicted)
- color
- Off-white to light yellow
- InChI
- InChI=1S/C24H23N5/c1-28-12-14-29(15-13-28)23-17-22(19-8-10-25-11-9-19)24(27-26-23)21-7-6-18-4-2-3-5-20(18)16-21/h2-11,16-17H,12-15H2,1H3
- InChIKey
- CIIVUDIZZJLXCN-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=C3C(=C2)C=CC=C3)=NN=C(N2CCN(C)CC2)C=C1C1C=CN=CC=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 33789
- Product name
- MW-150
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $43
- Updated
- 2026/04/30
- Product number
- 33789
- Product name
- MW-150
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $140
- Updated
- 2026/04/30
- Product number
- 33789
- Product name
- MW-150
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $194
- Updated
- 2026/04/30
- Product number
- 33789
- Product name
- MW-150
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $376
- Updated
- 2026/04/30
- Product number
- CS-0069509
- Product name
- MW-150
- Purity
- 99.90%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
MW-150 Chemical Properties,Usage,Production
Description
MW-150 (MW01-18-150SRM) is a selective, orally active, neurotransmitter p38α MAPK inhibitor with a Ki of 101 nM. It inhibits the ability of endogenous p38α MAPK to phosphorylate the endogenous substrate MK2 in activated glia.
Uses
MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
Biological Activity
MW-150 (MW01-18-150SRM) is a selective, orally active, neurotransmitter p38α MAPK inhibitor with a Ki of 101 nM. It inhibits the ability of endogenous p38α MAPK to phosphorylate the endogenous substrate MK2 in activated glia.
in vivo
MW-150 (2.5 mg/kg; oral daily for 3-4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests[1].
MW-150 (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1].
| Animal Model: | APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta)[1] |
| Dosage: | 2.5 mg/kg |
| Administration: | Oral daily; 3-4 months (until cognitive impairment is present) |
| Result: | Improved the Tg mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests. |
target
| p38α 101 nM (Ki) |
IC 50
p38α: 101 nM (Ki)
References
[1] Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80. DOI:10.1021/acschemneuro.5b00002
MW-150 Preparation Products And Raw materials
Raw materials
Preparation Products
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