ChemicalBook > CAS DataBase List > SBI-425

SBI-425

Product Name
SBI-425
CAS No.
1451272-71-1
Chemical Name
SBI-425
Synonyms
SBI-425;SBI-425 (SBI425);SBI-425, 10 mM in DMSO;SBI-425,Phosphatase,Inhibitor,SBI425,SBI 425,inhibit;5-(5-Chloro-2-methoxybenzenesulfonamido)pyridine-3-carboxamide;3-Pyridinecarboxamide, 5-[[(5-chloro-2-methoxyphenyl)sulfonyl]amino]-;5-[(5-chloro-2-methoxybenzene)sulfonamido]pyridine-3-carboxamide - [AC80942]
CBNumber
CB14668489
Molecular Formula
C13H12ClN3O4S
Formula Weight
341.77
MOL File
1451272-71-1.mol
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SBI-425 Property

Boiling point:
582.1±60.0 °C(Predicted)
Density 
1.509±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A solid
pka
6.21±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem
Product number
Axon2963
Product name
SBI-425
Purity
99%
Packaging
10mg
Price
$137.5
Updated
2021/12/16
ChemScene
Product number
CS-0087602
Product name
SBI-425
Purity
99.40%
Packaging
5mg
Price
$350
Updated
2021/12/16
Axon Medchem
Product number
Axon2963
Product name
SBI-425
Purity
99%
Packaging
50mg
Price
$467.5
Updated
2021/12/16
ChemScene
Product number
CS-0087602
Product name
SBI-425
Purity
99.40%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0087602
Product name
SBI-425
Purity
99.40%
Packaging
25mg
Price
$990
Updated
2021/12/16
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SBI-425 Chemical Properties,Usage,Production

Description

SBI-425 is a potent, selective and orally bioavailable compound that robustly inhibits tissue-nonspecific alkaline phosphatase (TNAP) in vivo.

Uses

SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival[1][2].

in vivo

1.19Mouse PK parameters for SBI-425[1]
CompdsSBI-425
Clp (mL/min/kg)5.14
Vd (L/kg)1.03
Cmax (μg/mL)178
AUC (μg*hr/mL)848
t1/2 (hr)2.3
%F58

References

[1] Pinkerton AB, et al. Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34. DOI:10.1016/j.bmcl.2017.11.024
[2] Sheen CR, et al. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30(5):824-36. DOI:10.1002/jbmr.2420
[3] Brichacek AL, et al. Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis. Sci Rep. 2019 Dec 11;9(1):18788. DOI:10.1038/s41598-019-55154-2

SBI-425 Preparation Products And Raw materials

Raw materials

Preparation Products

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SBI-425 Suppliers

China 41 United States 2 Global 43
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4786
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9166
Advantage
58
Shanghai Yu Ben Biotechnology Co., Ltd.
Tel
021-61350663 15502154572
Fax
-
Email
1639466865@qq.com
Country
China
ProdList
498
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Jingmo (Xiamen) Biotechnology Co., Ltd
Tel
13621943973; 13621943973
Email
sales@jamxmpharmatech.com
Country
China
ProdList
1169
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58

1451272-71-1, SBI-425Related Search:


  • SBI-425
  • 3-Pyridinecarboxamide, 5-[[(5-chloro-2-methoxyphenyl)sulfonyl]amino]-
  • SBI-425,Phosphatase,Inhibitor,SBI425,SBI 425,inhibit
  • SBI-425, 10 mM in DMSO
  • 5-(5-Chloro-2-methoxybenzenesulfonamido)pyridine-3-carboxamide
  • SBI-425 (SBI425)
  • 5-[(5-chloro-2-methoxybenzene)sulfonamido]pyridine-3-carboxamide - [AC80942]
  • 1451272-71-1