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TC-2153

Product Name
TC-2153
CAS No.
1381769-23-8
Chemical Name
TC-2153
Synonyms
TC-2153;TC-2153 >=95% (HPLC);TC-2153 hydrochloride;benzopentathiepin 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride
CBNumber
CB14668595
Molecular Formula
C7H5ClF3NS5
Formula Weight
355.87
MOL File
1381769-23-8.mol
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TC-2153 Property

storage temp. 
-20°C
solubility 
DMSO: 5mg/mL, clear
form 
powder
color 
white to beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1299
Product name
TC-2153
Purity
≥95% (HPLC)
Packaging
5MG
Price
$150
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1299
Product name
TC-2153
Purity
≥95% (HPLC)
Packaging
25MG
Price
$594
Updated
2025/07/31
DC Chemicals
Product number
DC21740
Product name
TC-2153
Purity
>98%
Packaging
100mg
Price
$950
Updated
2021/12/16
DC Chemicals
Product number
DC21740
Product name
TC-2153
Purity
>98%
Packaging
1g
Price
$3900
Updated
2021/12/16
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TC-2153 Chemical Properties,Usage,Production

Uses

TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling[1].

Biochem/physiol Actions

TC-2153 is a potent inhibitor of STEP (STriatal-Enriched protein tyrosine Phosphatase) that forms a reversible covalent bond with the catalytic cysteine in STEP. TC-2153 increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B in cell cultures. TC-2153 improves cognitive function in transgenic AD mice.

in vivo

Chronic TC-2153 treatment: TC-2153 (20 mg/kg; i.p.; once daily for 7 d) shows antidepressant-like effect without altering locomotor, exploratory activity and anxiety[1].
Acute TC-2153 treatment: TC-2153 (10 mg/kg and 20 mg/kg; p.o.; single dose) inhibits the functional activity of 5-HT2A receptors in vivo in mice[1].

Animal Model:SPF-state adult mouse males[1]
Dosage:10 mg/kg and 20 mg/kg; with or without 1 mg/kg DOI i.p. at 3 h after final treatment
Administration:Oral gavage or intraperitoneal injection; single dose or once daily for 7 d
Result:Showed antidepressant-like effect in the forced swim test without any adverse side effects on locomotor activity, anxiety, exploration, motor skill and obsessive-compulsive-like behavior.
Both acute and chronic methods inhibited the functional activity of 5-HT2A receptors.

IC 50

5-HT1A Receptor; 5-HT2A Receptor; MAO-A

References

[1] Walters JM, et al. Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity. Epilepsia. 2022 May;63(5):1211-1224. DOI:10.1111/epi.17192

TC-2153 Preparation Products And Raw materials

Raw materials

Preparation Products

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TC-2153 Suppliers

China 10 United States 1 Global 11
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
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80
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
doncunbiosci@gmail.com
Country
China
ProdList
544
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
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58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
ProdList
2742
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58
SuZhou GoodChemTech Co., Ltd
Tel
18136139868; 18136139868
Email
jinlun@goodchemtech.cn
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China
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284
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Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
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Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
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58
TargetMol Chemicals Inc.
Tel
+17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
19962
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58

1381769-23-8, TC-2153Related Search:

TC-O 9311 N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide

  • benzopentathiepin 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride
  • TC-2153
  • TC-2153 >=95% (HPLC)
  • TC-2153 hydrochloride
  • 1381769-23-8
  • C7H4F3NS5ClH