Valbenazine tosylate

Product Name: Valbenazine tosylate
CAS No.: 1639208-54-0
Chemical Name: Valbenazine tosylate
Synonyms: NBI-98854 Tosylate;Valbenzine tosylate;Valbenazine tosylate;Valbenazine Ditosylate;(S)-(2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate bis(4-methylbenzenesulfonate)
CBNumber: CB14675300
Molecular Formula: C31H46N2O7S
Formula Weight: 590.78
MOL File: 1639208-54-0.mol

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Valbenazine tosylate Property

storage temp.: Store at -20°C
solubility: DMSO: 100 mg/mL (131.07 mM);;

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Hazard and Precautionary Statements (GHS)

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Valbenazine tosylate Chemical Properties,Usage,Production

Uses

Valbenazine tosylate (NBI-98854 tosylate) is a vesicular monoamine transporter 2 (VMAT2) inhibitor with the Ki of 110-190 nM[1].

in vivo

Valbenazine (10 mg/kg; orally) induces ptosis (primarily an adrenergic response) and increases plasma prolactin primarily a dopaminergic response in rats^[1].

References

[1] Dimitri E Grigoriadis, et al. Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites. J Pharmacol Exp Ther. 2017 Jun;361(3):454-461. DOI:10.1124/jpet.116.239160

Valbenazine tosylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Valbenazine tosylate Suppliers

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Valbenazine Ditosylate

(S)-(2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate bis(4-methylbenzenesulfonate)

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1639208-54-0