2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione

Product Name: 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
CAS No.: 64567-60-8
Chemical Name: 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
Synonyms: Thalidomide-5-OH;Thalidomide Impurity 2;Thalidomide-5-OH, 10 mM in DMSO;4-Hydroxy thalidomide/Thalidomide-5-OH;Thalidomide 5-Hydroxyisoindoline Impurity;2-(2,6-dioxo-3-piperidyl)-5-hydroxy-isoindoline-1,3-dione;2-(2,6-Dioxo-3-piperidinyl)-5-hydroxy-1,3-isoindolinedione;2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione;2-(2,6-Dioxo-3-piperidinyl)-5-hydroxy-1H-isoindole-1,3(2H)-dione;1H-ISOINDOLE-1,3(2H)-DIONE,2-(2,6-DIOXO-3-PIPERIDINYL)-5-HYDROXY-
CBNumber: CB14675320
Molecular Formula: C13H10N2O5
Formula Weight: 274.23
MOL File: 64567-60-8.mol

More

Less

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Property

Melting point:: 317-318 °C
Boiling point:: 600.0±45.0 °C(Predicted)
Density: 1.611±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO: 62.5 mg/mL (227.91 mM)
pka: 7.06±0.20(Predicted)
form: Solid
color: Gray to brown
InChI: InChI=1S/C13H10N2O5/c16-6-1-2-7-8(5-6)13(20)15(12(7)19)9-3-4-10(17)14-11(9)18/h1-2,5,9,16H,3-4H2,(H,14,17,18)
InChIKey: LJBQRRQTZUJWRC-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=C(O)C=C2)C(=O)N1C1CCC(=O)NC1=O

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: D6178
Product name: 2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
Packaging: 1G
Price: $107
Updated: 2025/07/31

TCI Chemical

Product number: D6178
Product name: 2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
Packaging: 5G
Price: $321
Updated: 2025/07/31

Ambeed

Product number: A571532
Product name: 2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
Purity: 95%
Packaging: 100mg
Price: $15
Updated: 2021/12/16

Ambeed

Product number: A571532
Product name: 2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
Purity: 95%
Packaging: 250mg
Price: $25
Updated: 2021/12/16

Ambeed

Product number: A571532
Product name: 2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
Purity: 95%
Packaging: 1g
Price: $62
Updated: 2021/12/16

More

Less

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Chemical Properties,Usage,Production

Uses

Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

Definition

ChEBI: 5-Hydroxythalidomide is a member of phthalimides.

IC 50

Cereblon

References

[1] Megan G Marks, et al. Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation. Biol Pharm Bull. 2002 May;25(5):597-604. DOI:10.1248/bpb.25.597

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione Suppliers

China 98 United States 5 Global 103

Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd

Tel: 037188900765 18037465274
Fax: QQ3430974218
Email: enyawanglei@sina.cn
Country: China
ProdList: 13965
Advantage: 58

Abosyn

Tel: 0512-69561983 13914027025
Email: he_qf@medinoah.com
Country: China
ProdList: 3001
Advantage: 58

PharmaBlock Sciences (Nanjing),Inc.

Tel: 025-86918202 4000255188
Fax: 86-025-86918232
Email: sales@pharmablock.com
Country: China
ProdList: 5000
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7471
Advantage: 65

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Zouping Mingxing Chemical Co.,Ltd.

Tel: 86-13605431940 13605431940
Fax: 0086-0543-2240079
Email: zpmxchemical@126.com
Country: China
ProdList: 1490
Advantage: 62

More

Less

View Lastest Price from 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione 64567-60-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-18

Henan Fengda Chemical Co., Ltd

Product: 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione 64567-60-8
Price: US $8.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-29

64567-60-8, 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dioneRelated Search:

Thalidomide

2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione

2-(2,6-Dioxo-3-piperidinyl)-5-hydroxy-1H-isoindole-1,3(2H)-dione

1H-ISOINDOLE-1,3(2H)-DIONE,2-(2,6-DIOXO-3-PIPERIDINYL)-5-HYDROXY-

Thalidomide Impurity 2

Thalidomide-5-OH

Thalidomide 5-Hydroxyisoindoline Impurity

2-(2,6-Dioxo-3-piperidinyl)-5-hydroxy-1,3-isoindolinedione

4-Hydroxy thalidomide/Thalidomide-5-OH

Ligands for E3 Ligase,PROTAC,Inhibitor,Thalidomide5OH,inhibit,CRBN,E3 ligase-recruiting Moiety,Thalidomide,Thalidomide 5 OH

2-(2,6-dioxo-3-piperidyl)-5-hydroxy-isoindoline-1,3-dione

Thalidomide-5-OH, 10 mM in DMSO

2-(2,6-dioxo-3-piperidyl)-5-hydroxy-isoindoline-1,3-dione - [D87155]

64567-60-8