TRIFLUOPERAZINE DIMALEATE

Safety

Toxicity

LD50 orl-mus: 1150 mg/kg NIIRDN 6,524,82

Hazard and Precautionary Statements (GHS)

TRIFLUOPERAZINE DIMALEATE Chemical Properties,Usage,Production

Uses

Trifluoperazine dimaleate, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dimaleate is a potent α1-adrenergic receptor antagonist. Trifluoperazine dimaleate is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dimaleate is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dimaleate can be used for the research of schizophrenia. Trifluoperazine dimaleate acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].

Safety Profile

Poison by intravenous route.Moderately toxic by ingestion. When heated todecomposition it emits toxic fumes of Fí, SOx, and NOx.

References

[1] Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA. Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983;23(1):67-70. PMID:6135146
[2] Santofimia-Casta?o P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129(6):2500-2513. Published 2019 Mar 28. DOI:10.1172/JCI127223
[3] Marques LO, Lima MS, Soares BG. Trifluoperazine for schizophrenia. Cochrane Database Syst Rev. 2004;2004(1):CD003545. DOI:10.1002/14651858.CD003545.pub2
[4] Howland RH. Trifluoperazine: A Sprightly Old Drug. J Psychosoc Nurs Ment Health Serv. 2016;54(1):20-22. DOI:10.3928/02793695-20151223-01
[5] Ochiai H, et al. Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells. Antiviral Res. 1991;15(2):149-160. DOI:10.1016/0166-3542(91)90032-m