E3 ligase Ligand-Linker Conjugates 8

Product Name: E3 ligase Ligand-Linker Conjugates 8
CAS No.: 1835705-55-9
Chemical Name: E3 ligase Ligand-Linker Conjugates 8
Synonyms: VH032-C6-PEG3-C4-Cl;(S,R,S)-AHPC-6-2-2-6-Cl;VHL Ligand-Linker Conjugates 12;(S,R,S)-AHPC-C?-PEG?-butyl chloride;(S,R,S)-AHPC-C6-PEG3-butyl chloride;E3 ligase Ligand-Linker Conjugates 8;L-Prolinamide, N-[6-[2-[2-[(6-chlorohexyl)oxy]ethoxy]ethoxy]-1-oxohexyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-[(2S)-2-[6-(2-{2-[(6-chlorohexyl)oxy]ethoxy}ethoxy)hexanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;2S,4R)-1-((S)-2-(tert-Butyl)-22-chloro-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (S,R,S)-AHPC-6-2-2-6-Cl, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
CBNumber: CB14694703
Molecular Formula: C38H59ClN4O7S
Formula Weight: 751.42
MOL File: 1835705-55-9.mol

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E3 ligase Ligand-Linker Conjugates 8 Property

Boiling point:: 924.3±65.0 °C(Predicted)
Density: 1.174±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Ethanol: 100 mg/mL (133.08 mM); DMSO: ≥ 100 mg/mL (133.08 mM)
form: Oil
pka: 14.08±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 905380
Product name: (S,R,S)-AHPC-C6-PEG3-butyl chloride
Purity: ≥95%
Packaging: 50mg
Price: $342.6
Updated: 2024/03/01

Iris Biotech GmbH

Product number: PTC1750
Product name: (S,R,S)-AHPC-C6-PEG3-butyl-Cl
Packaging: 50mg
Price: $634.5
Updated: 2021/12/16

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E3 ligase Ligand-Linker Conjugates 8 Chemical Properties,Usage,Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-C₆-PEG₃-butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reactivity: sulfuryl reactive
reagent type: ligand-linker conjugate

E3 ligase Ligand-Linker Conjugates 8 Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 ligase Ligand-Linker Conjugates 8 Suppliers

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Sichuan Wei Keqi Biological Technology Co., Ltd.

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Sigma-Aldrich

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View Lastest Price from E3 ligase Ligand-Linker Conjugates 8 manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: (S,R,S)-AHPC-6-2-2-6-Cl 1835705-55-9
Price: US $0.00/mg
Min. Order: 100mg
Purity: >95.00%
Supply Ability: 100mg
Release date: 2024-04-01

1835705-55-9, E3 ligase Ligand-Linker Conjugates 8Related Search:

E3 ligase Ligand-Linker Conjugates 8

(S,R,S)-AHPC-C6-PEG3-butyl chloride

VHL Ligand-Linker Conjugates 12

VH032-C6-PEG3-C4-Cl

(S,R,S)-AHPC-6-2-2-6-Cl

L-Prolinamide, N-[6-[2-[2-[(6-chlorohexyl)oxy]ethoxy]ethoxy]-1-oxohexyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

2S,4R)-1-((S)-2-(tert-Butyl)-22-chloro-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (S,R,S)-AHPC-6-2-2-6-Cl, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate

(S,R,S)-AHPC-C?-PEG?-butyl chloride

(2S,4R)-1-[(2S)-2-[6-(2-{2-[(6-chlorohexyl)oxy]ethoxy}ethoxy)hexanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

1835705-55-9