1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE

Product Name: 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE
CAS No.: 27258-32-8
Chemical Name: 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE
Synonyms: AKOS B007390;3-Formyl-1-methyl-1H-pyrazole;1-Methylpyrazole-3-carbaldehyde;1-Methyl-3-pyrazolecarboxaldehyde;1-Methyl-1H-pyrazol-3-carbaldehyde;1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE;1-methyl-1H-Pyrazole-3-carboxaldehyde;1H-PYRAZOLE-3-CARBOXALDEHYDE, 1-METHYL-
CBNumber: CB1470473
Molecular Formula: C5H6N2O
Formula Weight: 110.11
MOL File: 27258-32-8.mol

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1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE Property

Boiling point:: 218.9±13.0℃ (760 Torr)
Density: 1.14±0.1 g/cm3 (20 ºC 760 Torr)
Flash point:: 86.2±19.8℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: liquid
pka: 0.06±0.10(Predicted)
color: light yellow
InChI: InChI=1S/C5H6N2O/c1-7-3-2-5(4-8)6-7/h2-4H,1H3
InChIKey: QUYJEYSRBCLJIZ-UHFFFAOYSA-N
SMILES: N1(C)C=CC(C=O)=N1
CAS DataBase Reference: 27258-32-8

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Safety

HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M320938
Product name: 1-Methyl-1H-pyrazole-3-carbaldehyde
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: M320938
Product name: 1-Methyl-1H-pyrazole-3-carbaldehyde
Packaging: 500mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: J50385
Product name: 1-Methyl-1H-pyrazole-3-carbaldehyde
Packaging: 5g
Price: $135
Updated: 2021/12/16

Matrix Scientific

Product number: 074671
Product name: 1-Methyl-1H-pyrazole-3-carbaldehyde
Purity: 95+%
Packaging: 5g
Price: $156
Updated: 2021/12/16

Apolloscientific

Product number: OR30991
Product name: 1-Methyl-1H-pyrazole-3-carboxaldehyde
Packaging: 1g
Price: $73
Updated: 2021/12/16

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1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE Chemical Properties,Usage,Production

Synthesis

67751-23-9

60-34-4

27258-32-8

Methylhydrazine (24 cm3, 19.5 g, 0.423 mol) was slowly added dropwise to 225 cm3 of aqueous solution containing 17.0 g NaOH (0.423 mol) under ice bath cooling conditions. Subsequently, 4-(dimethylamino)-1,1-dimethoxy-3-buten-2-one (73.3 g, 0.423 mol) was added slowly dropwise at room temperature and the reaction mixture was stirred overnight. After completion of the reaction, it was cooled to room temperature, 36% HCl (28.2 g, 0.278 mol) was added and stirring was continued for 1 hour. The reaction mixture was extracted with dichloromethane (4 x 100 cm3), the organic phases were combined and dried over anhydrous sodium sulfate. The solvent was removed by evaporation under reduced pressure and the residue was dissolved in 420 cm3 1M HCl aqueous solution and stirred at room temperature for 3 hours. Subsequently, the pH was adjusted to 10 with 10% K?CO? aqueous solution and extracted with dichloromethane (3 x 200 cm3). The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure. The residue was purified by vacuum distillation to give 1-methyl-1H-pyrazole-3-carbaldehyde (10a). Yield 32.8 g (70% yield); colorless liquid; boiling point: 70-72 °C (3 mbar); mass spectrum (ESI): m/z = 111 ([M + H]?) ; 1H NMR (500 MHz, CDCl?): δ = 9.84 (s, 1H), 7.36 (d, J = 1.4 Hz, 1H), 6.68 (d, J = 1.4 Hz, 1H), 3.91 (s, 3H) ppm; 13C NMR (126 MHz, CDCl?): δ = 185.8, 150.9, 131.8, 105.8, 39.2 ppm.

References

[1] Monatshefte fur Chemie, 2016, vol. 147, # 9, p. 1629 - 1636

1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE Suppliers

Belgium 1 China 130 Germany 2 India 2 United Kingdom 2 United States 17 Global 154

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View Lastest Price from 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE manufacturers

Career Henan Chemical Co

Product: 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE 27258-32-8
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

27258-32-8, 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDERelated Search:

ETHYL 1,5-DIMETHYL-1H-PYRAZOLE-3-CARBOXYLATE 4,4'-BIS[3-CARBOXY-5-OXO-1-(4-SULFOPHENYL)-2-PYRAZOLIN-4-YL]TRIMETHINE OXONOLE DIPOTASSIUM SALT Ethyl 5-amino-4-cyano-1-phenyl-1H-pyrazole-3-carboxylate 4-CHLORO-1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE,4-Chloro-1-methyl-1H-pyrazole-3-carbaldehyde, 95+% 4-BROMO-1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE,4-BROMO-1-METHYL-1H-PYRAZOLE-5-CARBALDEHYDE,4-BROMO-2-METHYL-2 H-PYRAZOLE-3-CARBALDEHYDE 1,5-DIMETHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID 1-ETHYL-3-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE LITHIUM 2-(MORPHOLINOMETHYL)BENZOATE, TECH 5-Methyl-1H-pyrazole-4-carbaldehyde 1,3-DIMETHYL-1H-PYRAZOLE-5-CARBALDEHYDE 5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE 1,5-DIMETHYL-1H-PYRAZOLE-3-CARBALDEHYDE 1,5-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE 3-CYCLOPROPYL-1-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde 1,3,5-Trimethyl-1H-pyrazole-4-carboxaldehyde 1-(4-METHOXYPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE 3-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE

1-Methylpyrazole-3-carbaldehyde

1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE

1H-PYRAZOLE-3-CARBOXALDEHYDE, 1-METHYL-

AKOS B007390

3-Formyl-1-methyl-1H-pyrazole

1-Methyl-1H-pyrazol-3-carbaldehyde

1-methyl-1H-Pyrazole-3-carboxaldehyde

1-Methyl-3-pyrazolecarboxaldehyde

27258-32-8

Building Blocks

Pyrazole