DIM-C-pPhCO2Me
- Product Name
- DIM-C-pPhCO2Me
- CAS No.
- 151358-48-4
- Chemical Name
- DIM-C-pPhCO2Me
- Synonyms
- DIM-C-pPhCO2Me;DIM-C-pPhCO2Me ，S6785;DIM-C-pPhCO2Me >=98% (HPLC);DIM-C-pPhCO2Me, 10 mM in DMSO;Methyl 4-(di(1H-indol-3-yl)methyl)benzoate;Benzoic acid, 4-(di-1H-indol-3-ylmethyl)-, methyl ester;DIM-C-pPhCO2Me Methyl 4-[bis(1H-indol-3-yl)methyl]benzoate;DIMCpPhCO2Me,DIM-C-pPhCO-2Me,inhibit,Inhibitor,DIM C pPhCO2Me
- CBNumber
- CB14718605
- Molecular Formula
- C25H20N2O2
- Formula Weight
- 380.44
- MOL File
- 151358-48-4.mol
DIM-C-pPhCO2Me Property
- Melting point:
- 98-100 °C
- Boiling point:
- 618.6±50.0 °C(Predicted)
- Density
- 1.287±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO:100.5(Max Conc. mg/mL);264.16(Max Conc. mM)
Ethanol:38.0(Max Conc. mg/mL);99.88(Max Conc. mM) - pka
- 16.34±0.30(Predicted)
- form
- Solid
- color
- Light yellow to yellow
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1976
- Product name
- DIM-C-pPhCO2Me
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $173
- Updated
- 2025/07/31
- Product number
- SML1976
- Product name
- DIM-C-pPhCO2Me
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $693
- Updated
- 2025/07/31
- Product number
- orb573406
- Product name
- DIM-C-pPhCO2Me
- Purity
- >98%
- Packaging
- 250mg
- Price
- $986
- Updated
- 2021/12/16
- Product number
- orb573406
- Product name
- DIM-C-pPhCO2Me
- Purity
- >98%
- Packaging
- 1g
- Price
- $2172.6
- Updated
- 2021/12/16
- Product number
- orb573406
- Product name
- DIM-C-pPhCO2Me
- Purity
- >98%
- Packaging
- 100mg
- Price
- $542.3
- Updated
- 2021/12/16
DIM-C-pPhCO2Me Chemical Properties,Usage,Production
Uses
DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhCO2Me induces Apoptosis. DIM-C-pPhCO2Me decreases PAX3-FOXO1A, N-Myc, Rassf4, MyoD1, Grem1, and DAPK1 proteins. DIM-C-pPhCO2Me decreases expression of TXNDC5 and IDH1, induces markers of ER stress (CHOP, ATF4 and p-PERK). DIM-C-pPhCO2Me inhibits renal cell carcinoma, breast cancer. DIM-C-pPhCO2Me can also be used in rhabdomyosarcoma research[1][2][3][4][5].
Biological Activity
DIM-C-pPhCO2Me is a NR4A1 (Nur77) antagonist th at exhibit potent anticancer activity in pancreatic, colon, breast, kidney, and rhabdomyosarcoma cells. DIM-C-pPhCO2Me decreases expression of PAX3-FOXO1A and β1-integrin proteins in Rh30 rhabdomyosarcoma and MDA-MB-231 breast cancer cells. DIM-C-pPhCO2Me inhibits migration of Rh30 and MDA-MB-231 cancer cells.', 'DIM-C-pPhCO2Me is also known as 1,1-bis(3μ-indolyl)-1-(p-carboxymethylphenyl)methane. In pancreatic and colon cancer cells, DIM-C-pPhCO2Me plays an inhibitory role on cell migration. DIM-C-pPhCO2Me prevents the action of mechanistic target of rapamycin (mTOR) and reduces the multiplication and survival of cancer cells. It stimulates reactive oxygen species (ROS) in various cancer cell lines.
in vivo
DIM-C-pPhCO2Me (2 mg/kg, single dose, intratracheally, 30 min before E. coliinfection) results in augmented phagocytic activity of AMs and reduces the mortality of mice with E. coli pneumonia[5].
| Animal Model: | Male mice with E. coli pneumonia[5] |
| Dosage: | 2 mg/kg, single dose |
| Administration: | intratracheally, 30 min before E. coli infection |
| Result: | Showed an obvious augmented phagocytic activity. Reduced the mortality in mice undergoing E. coli pneumonia (36.6% vs. 75%). |
IC 50
Nur77/NR4A1; IDH1
References
[1] Hedrick E, et al. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma. PLoS One. 2015 Jun 2;10(6):e0128308. DOI:10.1371/journal.pone.0128308
[2] Hedrick E, et al. Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy. Endocr Relat Cancer. 2015 Oct;22(5):831-40. DOI:10.1530/ERC-15-0063
[3] Lacey A, et al. Interleukin-24 (IL24) Is Suppressed by PAX3-FOXO1 and Is a Novel Therapy for Rhabdomyosarcoma. Mol Cancer Ther. 2018 Dec;17(12):2756-2766. DOI:10.1158/1535-7163.MCT-18-0118
[4] Lacey A, et al. PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1. Cancer Res. 2017 Feb 1;77(3):732-741. DOI:10.1158/0008-5472.CAN-16-1546
[5] Cui P, et al. Deficiency of the Transcription Factor NR4A1 Enhances Bacterial Clearance and Prevents Lung Injury During Escherichia Coli Pneumonia. Shock. 2019 Jun;51(6):787-794. DOI:10.1097/SHK.0000000000001184
DIM-C-pPhCO2Me Preparation Products And Raw materials
Raw materials
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