dTRIM24

Product Name: dTRIM24
CAS No.: 2170695-14-2
Chemical Name: dTRIM24
Synonyms: DTRM24;dTRIM24;(2S,4R)-1-((S)-15-(tert-Butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)sulfamoyl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-2-{2-[2-(2-{2-[(3-{[1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-1,3-benzodiazol-5-yl]sulfamoyl}phenyl)formamido]ethoxy}ethoxy)ethoxy]acetamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
CBNumber: CB14718706
Molecular Formula: C55H68N8O13S2
Formula Weight: 1113.31
MOL File: 2170695-14-2.mol

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dTRIM24 Property

Density: 1.316±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:61.14(Max Conc. mg/mL);54.96(Max Conc. mM)
Ethanol:22.27(Max Conc. mg/mL);20.02(Max Conc. mM)
form: Solid
pka: 9.35±0.20(Predicted)
color: White to off-white
InChIKey: QUQTXFIMYFMULC-VOCJROMSNA-N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2684
Product name: dTRIM24
Purity: ≥98% (HPLC)
Packaging: 1MG
Price: $92.05
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2684
Product name: dTRIM24
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $367
Updated: 2025/07/31

ChemScene

Product number: CS-0042317
Product name: dTRIM24
Purity: 98.20%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0042317
Product name: dTRIM24
Purity: 98.20%
Packaging: 25mg
Price: $1320
Updated: 2021/12/16

ChemScene

Product number: CS-0042317
Product name: dTRIM24
Purity: 98.20%
Packaging: 50mg
Price: $2450
Updated: 2021/12/16

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dTRIM24 Chemical Properties,Usage,Production

Uses

dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24.

Definition

dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24.

Biological Activity

dTRIM24, a conjugate of IACS-9571 a TRIM24 bromodomain ligand and VL-269 a VHL E3 ubiquitin ligase ligand, is a selective bifunctional degrader of bromodomain-containing transcriptional regulator TRIM24 (transcriptional intermediary factor 1a). dTRIM24 induces rapid and sustain proteasome degradation of TRIM24 in 293FT cells.

storage

Store at -20°C

References

[1] Gechijian LN, et al. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nat Chem Biol. 2018 Apr;14(4):405-412. DOI:10.1038/s41589-018-0010-y

dTRIM24 Preparation Products And Raw materials

Raw materials

Preparation Products

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dTRIM24 Suppliers

China 52 United States 3 Global 55

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Email: 2853979819@qq.com
Country: China
ProdList: 9998
Advantage: 58

Hubei Chuchang Chemical Co., Ltd

Tel: 18 15623560702
Email: info@chuchangbiotech.com
Country: China
ProdList: 162
Advantage: 58

Changzhou Borl Biotechnology Co.,LTD

Tel: 13606124132;13656121842
Email: luyan0021@163.com
Country: China
ProdList: 235
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

ShangHai Angti Biotechnology Co., Ltd.

Tel: 13764913901
Fax: -
Email: info@angtibio.com
Country: China
ProdList: 4985
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2989
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

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View Lastest Price from dTRIM24 manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: dTRIM24 2170695-14-2
Price: US $0.00/mg
Min. Order: 1mg
Purity: 98%min
Supply Ability: 500mg
Release date: 2021-08-26

Hubei Chuchang Biotech Co., Ltd.

Product: DTRIM24 2170695-14-2
Price: US $0.00-0.00/MG
Min. Order: 1MG
Purity: 98
Supply Ability: 100G
Release date: 2024-04-17

2170695-14-2, dTRIM24Related Search:

dTRIM24

DTRM24

(2S,4R)-1-((S)-15-(tert-Butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)sulfamoyl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

(2S,4R)-1-[(2S)-2-{2-[2-(2-{2-[(3-{[1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-1,3-benzodiazol-5-yl]sulfamoyl}phenyl)formamido]ethoxy}ethoxy)ethoxy]acetamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

2170695-14-2

C55H68N8O13S2