Methyl 1H-indole-7-carboxylate
- Product Name
- Methyl 1H-indole-7-carboxylate
- CAS No.
- 93247-78-0
- Chemical Name
- Methyl 1H-indole-7-carboxylate
- Synonyms
- RARECHEM AL BF 0640;Methyl 1H-indole-7-c;Methyl1H-indole-7-carboxyl;Methyl(7-indolecarboxylate);METHYL INDOLE-7-CARBOXYLATE;7-(Methoxycarbonyl)-1H-indole;METHYL 1H-INDOLE-7-CARBOXYLATE;7-INDOLECARBOXYLIC ACID METHYL ESTER;INDOLE-7-CARBOXYLIC ACID METHYL ESTER;1H-INDOLE-7-CARBOXYLIC ACID METHYL ESTER
- CBNumber
- CB1474204
- Molecular Formula
- C10H9NO2
- Formula Weight
- 175.18
- MOL File
- 93247-78-0.mol
Methyl 1H-indole-7-carboxylate Property
- Melting point:
- 47-48°C
- Boiling point:
- 331.7±15.0 °C(Predicted)
- Density
- 1.253±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 15.42±0.30(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C10H9NO2/c1-13-10(12)8-4-2-3-7-5-6-11-9(7)8/h2-6,11H,1H3
- InChIKey
- FTLOEULOTNVCGF-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2C(OC)=O)C=C1
- CAS DataBase Reference
- 93247-78-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-37/39
- WGK Germany
- WGK 3 highly water endangering
- HS Code
- 2933 99 80
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8.43864
- Product name
- Methyl(7-indolecarboxylate)
- Purity
- for synthesis
- Packaging
- 1g
- Price
- $211
- Updated
- 2023/01/07
- Product number
- M313593
- Product name
- MethylIndole-7-carboxylate
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 012660
- Product name
- Methyl 1H-indole-7-carboxylate
- Purity
- 98%
- Packaging
- 5g
- Price
- $52
- Updated
- 2021/12/16
- Product number
- OR10545
- Product name
- Methyl1H-indole-7-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $38
- Updated
- 2021/12/16
- Product number
- M670
- Product name
- Methylindole-7-carboxylate
- Packaging
- 5g
- Price
- $47
- Updated
- 2021/12/16
Methyl 1H-indole-7-carboxylate Chemical Properties,Usage,Production
Uses
Methyl Indole-7-carboxylate is useful for the preparation of inhibitors of CD38, which are useful in the treatment of cancer.
Synthesis
67-56-1
1670-83-3
93247-78-0
To a solution of 1H-indole-7-carboxylic acid (20 g, 124 mmol, 1.0 eq.) in methanol (700 ml) was slowly added concentrated sulfuric acid (1.2 g, 12 mmol, 0.1 eq.), the temperature of the reaction system was maintained at 0 °C and stirring was continued. The reaction mixture was heated to reflux and maintained for 20 hours. After completion of the reaction, methanol was evaporated under reduced pressure using a rotary evaporator. The residue was dissolved in ethyl acetate and the organic phase was washed sequentially with saturated sodium carbonate solution and brine. The organic layer was dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure to give Intermediate 1 (16.3 g, 75% yield) as a yellow solid.
References
[1] Patent: WO2013/4709, 2013, A1. Location in patent: Page/Page column 51
Methyl 1H-indole-7-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 1H-indole-7-carboxylate manufacturers
- Product
- Methyl 1H-indole-7-carboxylate 93247-78-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- Methyl 1H-indole-7-carboxylate in stock Factory 93247-78-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 production capacity Factory
- Release date
- 2019-04-03
- Product
- Methyl 1H-indole-7-carboxylate in stock Factory 93247-78-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 production capacity Factory
- Release date
- 2019-04-03