3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]pyridine

Product Name: 3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]pyridine
CAS No.: 2117405-13-5
Chemical Name: 3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]pyridine
Synonyms: SEN177;SEN 177;SEN177;SEN 177;3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]pyridine
CBNumber: CB14767254
Molecular Formula: C18H19FN6
Formula Weight: 338.38
MOL File: 2117405-13-5.mol

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3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]pyridine Property

Boiling point:: 581.3±60.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO:36.0(Max Conc. mg/mL);106.3(Max Conc. mM)
pka: 6.72±0.31(Predicted)
form: Solid
color: Brown to gray

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb573418
Product name: SEN-177
Purity: >98%
Packaging: 100mg
Price: $1060.8
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573418
Product name: SEN-177
Purity: >98%
Packaging: 250mg
Price: $1802
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573418
Product name: SEN-177
Purity: >98%
Packaging: 1g
Price: $4023.9
Updated: 2021/12/16

DC Chemicals

Product number: DC20240
Product name: SEN-177
Purity: >98%
Packaging: 100mg
Price: $700
Updated: 2021/12/16

DC Chemicals

Product number: DC20240
Product name: SEN-177
Purity: >98%
Packaging: 1g
Price: $2700
Updated: 2021/12/16

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3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]pyridine Chemical Properties,Usage,Production

Definition

ChEBI: SEN177 is a member of bipyridines.

Biological Activity

SEN177 is a Glutaminyl cyclase (QPCT) inhibitor. Glutaminyl cyclase modifies N-terminal glutamine or glutamate residues to N-terminal 5-oxoproline or pyroglutamate (named QPCT). QPCT inhibits mutant huntingtin from forming aggregates, but also reduces aggregation of other aggregate-prone proteins containing polyQ or polyA repeats. SEN177 caused dose-dependent decreases in HTT aggregation by a mechanism th at requires QPCT inhibition. SEN177 had in vitro activity against polyglutamine toxicity and was able to reduce aggregates in mammalian cells, primary neurons and in a Drosophila model.

storage

Store at -20°C

3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]pyridine Suppliers

China 14 Global 14

ShangHai Wisacheam Pharmaceutical Co., Ltd.

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Aikon International Limited

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Fax: (6)02557626880
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Angel Pharmatech, Ltd.

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DC Chemicals

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Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd

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Olix (Shanghai) Pharmaceutical Technology Co., Ltd

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2117405-13-5, 3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]pyridineRelated Search:

3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]pyridine

SEN 177

SEN177

SEN177;SEN 177

2117405-13-5