KYL
- Product Name
- KYL
- CAS No.
- 676657-00-4
- Chemical Name
- KYL
- Synonyms
- KYL;KYL TFA;KYL peptide;KYLPYWPVLSSL;L-Leucine, L-lysyl-L-tyrosyl-L-leucyl-L-prolyl-L-tyrosyl-L-tryptophyl-L-prolyl-L-valyl-L-leucyl-L-seryl-L-seryl-
- CBNumber
- CB14796559
- Molecular Formula
- C74H108N14O17
- Formula Weight
- 1465.73
- MOL File
- 676657-00-4.mol
KYL Property
- Boiling point:
- 1728.5±65.0 °C(Predicted)
- Density
- 1.290±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 3.29±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Soluble to 2 mg/ml in water
- Sequence
- H-Lys-Tyr-Leu-Pro-Tyr-Trp-Pro-Val-Leu-Ser-Ser-Leu-OH
N-Bromosuccinimide Price
- Product number
- SML1378
- Product name
- KYL trifluoroacetate salt
- Purity
- ≥95% (HPLC)
- Packaging
- 1 mg
- Price
- $189
- Updated
- 2025/07/31
- Product number
- 5290
- Product name
- KYL
- Packaging
- 1
- Price
- $181
- Updated
- 2021/12/16
- Product number
- 255617
- Product name
- KYL
- Packaging
- 1mg
- Price
- $432
- Updated
- 2021/12/16
KYL Chemical Properties,Usage,Production
Uses
KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor (IC50:4.22 μM, Kd:1.3 μM). KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses[1][2][3].
Biological Activity
KYL is a potent and selective EphA4 receptor tyrosine kinase antagonist th at inhibits EphA4-EphrinA5 interactions. KYL binds to the ephrin-binding domain of EphA4.
IC 50
EphA4: 4.22 μM μM (IC50); EphA4: 1.30 μM (Ki)
storage
Store at -20°C
References
[1] Wu B, et.al. HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery. Chem Biol. 2013 Jan 24;20(1):19-33. DOI:10.1016/j.chembiol.2012.10.015
[2] Lamberto I, et, al. Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem J. 2012 Jul 1;445(1):47-56. DOI:10.1042/BJ20120408
[3] Fu AKY, et, al. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9959-64. DOI:10.1073/pnas.1405803111
KYL Preparation Products And Raw materials
Raw materials
Preparation Products
KYL Suppliers
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- info@creative-peptides.com
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