Delcasertib

Product Name: Delcasertib
CAS No.: 949100-39-4
Chemical Name: Delcasertib
Synonyms: KAI-9803;BMS-875944;Delcasertib;Delcasertib, 10 mM in DMSO;BMS875944,Inhibitor,BMS 875944,KAI 9803,Delcasertib,inhibit,Protein kinase C,PKC,KAI9803;L-Arginine, L-cysteinyl-L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-, (1→1')-disulfide with L-cysteinyl-L-seryl-L-phenylalanyl-L-asparaginyl-L-seryl-L-tyrosyl-L-α-glutamyl-L-leucylglycyl-L-seryl-L-leucine
CBNumber: CB14797046
Molecular Formula: C120H199N45O34S2
Formula Weight: 2880.31
MOL File: 949100-39-4.mol

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Delcasertib Property

Density: 1.54±0.1 g/cm3(Predicted)
solubility: DMSO:100.0(Max Conc. mg/mL);34.72(Max Conc. mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0025460
Product name: Delcasertib
Purity: 98.21%
Packaging: 5mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0025460
Product name: Delcasertib
Purity: 98.21%
Packaging: 10mg
Price: $990
Updated: 2021/12/16

ChemScene

Product number: CS-0025460
Product name: Delcasertib
Purity: 98.21%
Packaging: 25mg
Price: $1990
Updated: 2021/12/16

ChemScene

Product number: CS-0025460
Product name: Delcasertib
Purity: 98.21%
Packaging: 50mg
Price: $2750
Updated: 2021/12/16

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Delcasertib Chemical Properties,Usage,Production

Uses

Delcasertib (KAI-9803) is a potent and selective δ-protein kinase C (δPKC) inhibitor. Delcasertib (KAI-9803) could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI)[1][2].

in vivo

Delcasertib (KAI-9803, a single intraperitoneal injection) in mice results in the selective inhibition of PKC translocation in the liver, kidney, lung, heart, and brain^[1].
Delcasertib (KAI-9803) administration at the end of ischemia has been found to reduce cardiac damage caused by ischemia-reperfusion in a rat model of acute myocardial infarction^[1].
Delcasertib (KAI-9803) has been studied for the prevention of reperfusion injury in patients undergoing angioplasty after acute myocardial infarction^[2].

Animal Model:	Six-week-old male Crl:CD(SD) rats^[1].
Dosage:	1 mg/kg (Pharmacokinetic Analysis).
Administration:	Via the femoral vein.
Result:	The distribution to tissues such as the liver, kidney, and heart is facilitated by the reversible conjugation to TAT47-57.

IC 50

δPKC

References

[1] Miyaji Y, et al. Distribution of KAI-9803, a novel δ-protein kinase C inhibitor, after intravenous administration to rats. Drug Metab Dispos. 2011 Oct;39(10):1946-53. DOI:10.1124/dmd.111.040725
[2] Bates E, et al. Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Circulation. 2008 Feb 19;117(7):886-96. DOI:10.1161/CIRCULATIONAHA.107.759167

Delcasertib Preparation Products And Raw materials

Raw materials

Preparation Products

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Delcasertib Suppliers

China 30 United States 5 Global 35

Creative Peptides

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949100-39-4, DelcasertibRelated Search:

Delcasertib

KAI-9803

BMS-875944

BMS875944,Inhibitor,BMS 875944,KAI 9803,Delcasertib,inhibit,Protein kinase C,PKC,KAI9803

L-Arginine, L-cysteinyl-L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-, (1→1')-disulfide with L-cysteinyl-L-seryl-L-phenylalanyl-L-asparaginyl-L-seryl-L-tyrosyl-L-α-glutamyl-L-leucylglycyl-L-seryl-L-leucine

Delcasertib, 10 mM in DMSO

949100-39-4